Olver W J, Scott F, Shankland G S
Department of Medical Microbiology, Ninewells Hospital, Dundee, UK.
Med Mycol. 2006 Nov;44(7):655-7. doi: 10.1080/13693780600686929.
We report a leukemic patient with C. krusei fungemia who failed to respond to liposomal amphotericin B therapy alone. The addition of caspofungin eradicated infection and was well tolerated. Our report is the first to describe successful treatment of a patient with invasive C. krusei infection using this combination of antifungals. Combination therapy could be a useful treatment option for invasive candidosis, particularly when caused by more resistant species such as C. krusei.
我们报告了一名患有克鲁斯念珠菌血症的白血病患者，其单独使用脂质体两性霉素B治疗无效。加入卡泊芬净后感染得以根除，且耐受性良好。我们的报告首次描述了使用这种抗真菌药物组合成功治疗侵袭性克鲁斯念珠菌感染患者的情况。联合治疗可能是侵袭性念珠菌病的一种有效治疗选择，特别是由克鲁斯念珠菌等更具耐药性的菌种引起的感染。
