Green J, Berrington de Gonzalez A, Smith J S, Franceschi S, Appleby P, Plummer M, Beral V
Cancer Research UK Epidemiology Unit, University of Oxford, Gibson Building, Radcliffe Infirmary, UK.
Br J Cancer. 2003 Jun 2;88(11):1713-20. doi: 10.1038/sj.bjc.6600971.
Human papillomavirus (HPV) infection is thought to be a necessary but not sufficient cause of most cases of cervical cancer. Since oral contraceptive use for long durations is associated with an increased risk of cervical cancer, it is important to know whether HPV infection is more common in oral contraceptive users. We present a systematic review of 19 epidemiological studies of the risk of genital HPV infection and oral contraceptive use. There was no evidence for a strong positive or negative association between HPV positivity and ever use or long duration use of oral contraceptives. The limited data available, the presence of heterogeneity between studies and the possibility of bias and confounding mean, however, that these results must be interpreted cautiously. Further studies are needed to confirm these findings and to investigate possible relations between oral contraceptive use and the persistence and detectability of cervical HPV infection.
人乳头瘤病毒（HPV）感染被认为是大多数宫颈癌病例的必要但非充分病因。由于长期使用口服避孕药会增加患宫颈癌的风险，因此了解HPV感染在口服避孕药使用者中是否更为常见很重要。我们对19项关于生殖器HPV感染风险与口服避孕药使用的流行病学研究进行了系统综述。没有证据表明HPV阳性与曾经使用或长期使用口服避孕药之间存在强烈的正相关或负相关。然而，现有数据有限、研究之间存在异质性以及存在偏倚和混杂因素的可能性意味着，这些结果必须谨慎解读。需要进一步的研究来证实这些发现，并调查口服避孕药使用与宫颈HPV感染的持续性和可检测性之间可能存在的关系。
