树突状细胞对免疫反应的调节：白细胞介素2在固有免疫和适应性免疫交叉点的新作用。
Dendritic cell regulation of immune responses: a new role for interleukin 2 at the intersection of innate and adaptive immunity.
作者信息
Granucci Francesca, Zanoni Ivan, Feau Sonia, Ricciardi-Castagnoli Paola
机构信息
University of Milano-Bicocca, Department of Biotechnology and Bioscience, Milan, Italy.
出版信息
EMBO J. 2003 Jun 2;22(11):2546-51. doi: 10.1093/emboj/cdg261.
Abstract
Dendritic cells are professional antigen-presenting cells able to initiate innate and adaptive immune responses against invading pathogens. In response to external stimuli dendritic cells undergo a complete genetic reprogramming that allows them to become, soon after activation, natural killer cell activators and subsequently T cell stimulators. The recent observation that dendritic cells produce interleukin 2 following microbial stimulation opens new possibilities for understanding the efficiency of dendritic cells in regulating immune system functions. This review discusses how dendritic cells control natural killer, T- and B-cell responses and the relevance of interleukin 2 in these processes.
摘要
树突状细胞是专职抗原呈递细胞，能够启动针对入侵病原体的先天性和适应性免疫反应。响应外部刺激时，树突状细胞会经历完全的基因重编程，使其在激活后不久能够成为自然杀伤细胞激活剂，随后成为T细胞刺激剂。最近观察到树突状细胞在微生物刺激后产生白细胞介素2，这为理解树突状细胞在调节免疫系统功能方面的效率开辟了新的可能性。本文综述了树突状细胞如何控制自然杀伤细胞、T细胞和B细胞反应以及白细胞介素2在这些过程中的相关性。
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