马来酸哌克昔林对缺血犬心肌冠脉血流分布的影响。
Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium.
作者信息
Klassen G A, Sestier F, L'Abbate A, Mildenberger R R, Zborowska-Sluis D T
出版信息
Circulation. 1976 Jul;54(1):14-20. doi: 10.1161/01.cir.54.1.14.
PMID:1277417
Abstract
Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic-induced left ventricular failure.
摘要
在具有固定冠脉血流量的犬类制剂中，静脉注射马来酸哌克昔林可增加冠脉舒张压。它还能重新分配冠脉血流，以维持心内膜血流。该药物可降低心肌耗氧量并增强乳酸摄取。它对缺血性左心室衰竭的阈值没有影响。
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