Ammann B, Wüthrich B
Dtsch Med Wochenschr. 1985 Aug 16;110(33):1239-45. doi: 10.1055/s-2008-1068989.
Among sera from 379 patients with atopy tested with the radio-allergo-sorbent test (RAST) for domestic dust and house-dust mite (Dermatophagoides pteronyssinus), 104 were positive only for house dust. Positive results for both house dust and house-dust mites were obtained in 130, while in 145 the RAST result was positive only for house-dust mites. 104 sera, negative for house-dust mites, were tested by RAST for specific IgE against epithelia from cats, dogs, guinea-pigs, horses and cattle, as well as cockroaches (Blatella germanica). A positive RAST result for at least one of these animal epithelia was obtained in 89.5% of sera, for cockroaches in 7.7%. Cat epithelia were of special importance with respect to both rate and degree of sensitization. Except for dog epithelia, sensitization (as demonstrated with RAST) against the other domestic animal epithelia was more frequent than the history had indicated. After immune-adsorption of its homologous specific IgE with cat epithelia, but not after adsorption with epithelia of dog, guinea-pig, horse and cattle, inhibition of the house-dust RAST level in 60-80% was demonstrated in pool-sera. This finding proves that sensitization to cat epithelia, in addition to house-dust mites, can be the cause of a positive house-dust RAST reaction; cat epithelia are an important allergen of inhalation allergies caused by house dust.
在对379例特应性患者血清进行家用灰尘和屋尘螨（粉尘螨）放射性变应原吸附试验（RAST）检测时，104例仅对家用灰尘呈阳性。130例对家用灰尘和屋尘螨均呈阳性，而145例RAST结果仅对屋尘螨呈阳性。对104例屋尘螨阴性的血清进行RAST检测，以检测针对猫、狗、豚鼠、马和牛的上皮细胞以及蟑螂（德国小蠊）的特异性IgE。89.5%的血清对这些动物上皮细胞中至少一种的RAST结果呈阳性，对蟑螂的阳性率为7.7%。猫上皮细胞在致敏率和致敏程度方面都特别重要。除狗上皮细胞外，（通过RAST显示）对其他家畜上皮细胞的致敏比病史所显示的更频繁。用猫上皮细胞免疫吸附其同源特异性IgE后，但用狗、豚鼠、马和牛的上皮细胞吸附后则未出现这种情况，混合血清中家用灰尘RAST水平有60 - 80%受到抑制。这一发现证明，除屋尘螨外，对猫上皮细胞的致敏可能是家用灰尘RAST反应呈阳性的原因；猫上皮细胞是由家用灰尘引起的吸入性过敏的重要变应原。
