采用序贯粪便潜血试验对北京市自然人群进行结直肠癌筛查：一项多中心研究。
Colorectal cancer screening for the natural population of Beijing with sequential fecal occult blood test: a multicenter study.
作者信息
Li Shirong, Nie Zhaohua, Li Nan, Li Junxiang, Zhang Ping, Yang Zhaoxu, Mu Shankun, Du Yaping, Hu Jichun, Yuan Shenyuan, Qu Hanting, Zhang Taichang, Wang Shixin, Dong Enyu, Qi Defang
机构信息
Department of Gastroenterology, General Hospital of Beijing Military Region, Beijing 100700, China.
出版信息
Chin Med J (Engl). 2003 Feb;116(2):200-2.
OBJECTIVE
To assess the prevalence of colorectal cancer (CRC) in Beijing and the reliability of the sequential fecal occult blood test (SFOBT) for CRC screening.
METHODS
Of the natural population (48 100 persons) in several Beijing communities, we screened 26 827 persons with age over 30 using the SFOBT screening program, Guaiacum Fecal Occult Blood Test (GFOBT), Immuno Fecal Occult Blood Test (IFOBT), and colonoscopies.
RESULTS
The screening rate of the population was 74%. The positive rate of SFOBT was 5.6%. The prevalence of CRC in the entire population of Beijing was therefore calculated to be 36.57/10(5). Of 12 CRC detected patients, 4 cases were in stage Dukes A (33.33%), 7 cases in stage Dukes B (58.33%), only 1 case (8.34%) in stage Dukes C.
CONCLUSIONS
The prevalence of CRC in Beijing is one of the highest in China. Individuals at high risk for CRC or those over 50 years of age should be considered as primary candidates for screening. SFOBT screening is a cost-effective and reliable method for early detection of CRC.
目的
评估北京地区结直肠癌（CRC）的患病率以及序贯粪便潜血试验（SFOBT）用于CRC筛查的可靠性。
方法
在北京市多个社区的自然人群（48100人）中，我们使用SFOBT筛查方案、愈创木脂粪便潜血试验（GFOBT）、免疫粪便潜血试验（IFOBT）和结肠镜检查，对26827名30岁以上人群进行了筛查。
结果
人群筛查率为74%。SFOBT阳性率为5.6%。据此计算出北京地区全体人群CRC患病率为36.57/10万。在检测出的12例CRC患者中，4例为Dukes A期（33.33%），7例为Dukes B期（58.33%），仅1例（8.34%）为Dukes C期。
结论
北京地区CRC患病率为全国最高之一。CRC高危个体或50岁以上人群应被视为筛查的主要对象。SFOBT筛查是早期发现CRC的一种经济有效的可靠方法。
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