Merendino Rosaria Alba, Salvo Francesco, Saija Antonella, Di Pasquale Giuseppe, Tomaino Antonio, Minciullo Paola Lucia, Fraccica Giuseppe, Gangemi Sebastiano
Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Italy.
Mediators Inflamm. 2003 Apr;12(2):127-8. doi: 10.1080/0962935031000097745.
Benign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomarker of oxidative stress. Prostate-specific antigen (PSA) is a sensitive marker for prostatic hypertrophy and cancer. We analyzed MDA serum levels to evaluate the oxidative stress in BPH. To this end, 22 BPH patients and 22 healthy donors were enrolled. Data show an increase of MDA level in BPH patients and a positive correlation between PSA and MDA levels. In conclusion, we describe a previously unknown relationship between PSA and MDA as an index of inflammation and oxidative stress in BPH.
良性前列腺增生(BPH)是男性最常见的良性肿瘤,可导致尿道梗阻,最终引发尿毒症。丙二醛(MDA)是多不饱和脂肪酸及其相关酯过氧化反应的产物。血清中MDA的评估是氧化应激的一种非侵入性生物标志物。前列腺特异性抗原(PSA)是前列腺肥大和癌症的敏感标志物。我们分析了血清MDA水平以评估BPH中的氧化应激。为此,招募了22名BPH患者和22名健康捐赠者。数据显示BPH患者的MDA水平升高,且PSA与MDA水平呈正相关。总之,我们描述了PSA与MDA之间一种先前未知的关系,这种关系可作为BPH中炎症和氧化应激的指标。