Sadeghimanesh Arezo, Gholipour Sajedeh, Torki Akram, Amini-Khoei Hossein, Lorigooini Zahra, Habtemariam Solomon
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Pharmacognosy Research Laboratories and Herbal Analysis Services UK, University of Greenwich, Chatham-Maritime, Kent, ME4 4TB, UK.
Biomedicine (Taipei). 2021 Mar 1;11(1):19-25. doi: 10.37796/2211-8039.1083. eCollection 2021.
Benign prostatic hyperplasia (BPH) is the most prevalent disease of the prostate in elderly men. Since has been reported to show various pharmacological effects, this study was conducted to examine the effect of . seed oil on experimental BPH.
The oil was extracted using the cold-pressing method. Fifty rats were divided into five groups of 10 each as follows: Group 1 orally (p.o.) received normal saline; groups 2-5 were castrated and subcutaneously received 5 mg/kg testosterone propionate for four weeks. Group 2, namely, BPH model, underwent no further treatment, Groups 3 and 4 were treated with 400 mg/kg and 800 mg/kg seed oil, Group 5 received finasteride (0.5 mg/kg, p.o.) for 28 days. All groups received repeated testosterone injections for the following four weeks after BPH induction. After the treatments, rats were sacrificed and the prostate tissues removed. Wet weight, prostatic volume (PV) and prostatic index (PI) were determined. Serum prostate-specific antigen (PSA), dihydrotestosterone (DHT), malondialdehyde (MDA) and antioxidant levels were determined.
Our results showed that oral treatment with 400 and 800 mg/kg oil led to a significant decrease in PI, PV, DHT concentration, PSA, and serum MDA level, and also significantly increased serum antioxidant capacity.
The study demonstrated that the oil seed exerted anti-BPH effects which may be associated with its antioxidant properties .
良性前列腺增生（BPH）是老年男性中最常见的前列腺疾病。由于据报道[具体物质]具有多种药理作用，本研究旨在探讨[具体物质]籽油对实验性BPH的影响。
采用冷压法提取油。50只大鼠分为五组，每组10只，分组如下：第1组口服生理盐水；第2 - 5组去势后皮下注射5 mg/kg丙酸睾酮，持续四周。第2组即BPH模型组，不做进一步处理，第3组和第4组分别用400 mg/kg和800 mg/kg的[具体物质]籽油处理，第5组口服非那雄胺（0.5 mg/kg），持续28天。在诱导BPH后的接下来四周，所有组均重复注射睾酮。处理后，处死大鼠并取出前列腺组织。测定湿重、前列腺体积（PV）和前列腺指数（PI）。测定血清前列腺特异性抗原（PSA）、二氢睾酮（DHT）、丙二醛（MDA）和抗氧化剂水平。
我们的结果表明，口服400和800 mg/kg的[具体物质]油可导致PI、PV、DHT浓度、PSA和血清MDA水平显著降低，同时血清抗氧化能力也显著提高。
该研究表明，[具体物质]籽油具有抗BPH作用，这可能与其抗氧化特性有关。
