Akazawa Hiroshi, Komuro Issei
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
Circ Res. 2003 May 30;92(10):1079-88. doi: 10.1161/01.RES.0000072977.86706.23.
Different cell types, equipped with unique structure and function, synthesize different sets of proteins on the basis of different patterns of gene expression, even though their genomes are identical. Cardiac transcription factors have been reported to control a cardiac gene program and thus to play a crucial role in transcriptional regulation during embryogenesis. Recently, postnatal roles of cardiac transcription factors have been extensively investigated. Consistent with the direct transactivation of numerous cardiac genes reactivated in response to hypertrophic stimulation, cardiac transcription factors are profoundly involved in the generation of cardiac hypertrophy or in cardioprotection from cytotoxic stress in the adult heart. In this review, the regulation of a cardiac gene program by cardiac transcription factors is summarized, with an emphasis on their potential role in the generation of cardiac hypertrophy.
不同的细胞类型具有独特的结构和功能，尽管它们的基因组相同，但基于不同的基因表达模式会合成不同的蛋白质组。据报道，心脏转录因子可控制心脏基因程序，从而在胚胎发育过程中的转录调控中发挥关键作用。最近，人们对心脏转录因子在出生后的作用进行了广泛研究。与因肥厚性刺激而重新激活的众多心脏基因的直接反式激活一致，心脏转录因子在成体心脏中深刻参与心脏肥大的发生或对细胞毒性应激的心脏保护作用。在本综述中，总结了心脏转录因子对心脏基因程序的调控，重点强调了它们在心脏肥大发生中的潜在作用。
