Singh Betsy B, Mishra Lakshmi C, Vinjamury Sivarama Prasad, Aquilina Nanette, Singh Vijay J, Shepard Neil
Southern California University of Health Sciences, USA.
Altern Ther Health Med. 2003 May-Jun;9(3):74-9.
Ayurveda, the traditional system of healthcare in India, has many remedies for Osteoarthritis (OA). One of the ingredients most commonly found in Ayurvedic arthritis formulas is guggul, an oleoresin of the herb Commiphora mukul (CM). The authors have conducted both preclinical and clinical investigations of guggul for reduction of pain, stiffness, and improved function, and to determine tolerability in older patients with a diagnosis of OA of the knee.
The study was conducted using an outcome, quasi-experimental, model. Thirty male and female participants meeting the inclusion/exclusion criteria, with a score of 2 or more on the Kellegran-Lawrence scale for at least 1 knee, were admitted in the study. CM was administered in capsule form (500 mg concentrated exact delivered TID) along with food. The WOMAC Total Score was used as a primary outcome measure. VAS scales, 6-minute walk-test, and WOMAC subscales were used as outcome measures.
At the end of treatment, there was a significant difference in the scores of the primary and secondary outcome measures. On the primary measure, WOMAC total score, participants were significantly improved (P < 0.0001) after taking the supplement for 1 month and continued to improve at the 2-month marker and follow-up. Secondary measures of pain in the VAS format demonstrated participant improvement; however, mood state, and current pain were not significantly different (P < 0.05) than baseline until the 2 month assessment (P < 0.001).
Overall data indicate significant improvement for participants during the trial in both scales and objective measures used for assessment purposes. There were no side effects reported during the trial. CM appears to be a relatively safe and effective supplement to reduce symptoms of OA.
阿育吠陀医学是印度传统的医疗体系，有多种治疗骨关节炎（OA）的疗法。阿育吠陀关节炎配方中最常见的成分之一是古古勒，它是药用没药树（CM）的一种油性树脂。作者对古古勒进行了临床前和临床研究，以减轻疼痛、僵硬并改善功能，并确定其在诊断为膝骨关节炎的老年患者中的耐受性。
该研究采用了一种基于结果的准实验模型。30名符合纳入/排除标准、至少一侧膝关节在Kellegran-Lawrence量表上得分2分或更高的男性和女性参与者被纳入研究。CM以胶囊形式（500毫克浓缩精确剂量，每日三次）与食物一起服用。WOMAC总分用作主要结局指标。视觉模拟评分量表（VAS）、6分钟步行试验和WOMAC子量表用作结局指标。
治疗结束时，主要和次要结局指标的得分有显著差异。在主要指标WOMAC总分方面，参与者在服用补充剂1个月后有显著改善（P < 0.0001），并在2个月标记点和随访时持续改善。VAS格式的疼痛次要指标显示参与者有所改善；然而，直到2个月评估时（P < 0.001），情绪状态和当前疼痛与基线相比才存在显著差异（P < 0.05）。
总体数据表明，在试验期间，参与者在用于评估目的的量表和客观指标方面均有显著改善。试验期间未报告任何副作用。CM似乎是一种相对安全有效的补充剂，可减轻OA症状。
