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芳香植物作为对抗骨关节炎的潜在资源

Aromatic Plants as Potential Resources to Combat Osteoarthritis.

作者信息

Maring Maphibanri, Balaji C, Komala M, Nandi Sisir, Latha S, Raghavendran H Balaji

机构信息

Department of Pharmacognosy, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, India.

Department of Rheumatology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, India.

出版信息

Comb Chem High Throughput Screen. 2024;27(10):1434-1465. doi: 10.2174/0113862073267213231004094629.

Abstract

Osteoarthritis, which affects an estimated 10% of men and 18% of women over the age of 60 and is increasing in genetic prevalence and incidence, is acknowledged as the condition that degrades the quality of life for older adults in the world. There is currently no known treatment for osteoarthritis. The majority of therapeutic methods slow the progression of arthritis or treat its symptoms, making effective treatment to end the degenerative process of arthritis elusive. When non-pharmacological therapy is ineffective, various pharmacological therapies may be used to treat osteoarthritis. Pharmacological therapy, however, can have major adverse effects and be very expensive. As a result, alternative remedies have been researched. The promise for the safe and efficient management of osteoarthritis has been demonstrated by herbal remedies. Experimental research suggests that herbal extracts and compounds can reduce inflammation, inhibit catabolic processes, and promote anabolic processes that are important for treating osteoarthritis. Due to their therapeutic and innate pharmacological qualities, aromatic herbs are frequently employed as herbal remedies. Recent research has shown that aromatic plants have the potency to treat osteoarthritis. Additionally, complex mixtures of essential oils and their bioactive ingredients, which have anti-inflammatory and antioxidant properties and are obtained from aromatic plants, are frequently utilized as complementary therapies for osteoarthritis. To establish new study avenues, the advantageous anti-osteoarthritic effects of aromatic herbal medicines, including plants, essential oils, and their bioactive components, are extensively discussed.

摘要

骨关节炎影响着约10%的60岁以上男性和18%的60岁以上女性,其遗传患病率和发病率正在上升,被公认为是降低全球老年人生活质量的疾病。目前尚无已知的骨关节炎治疗方法。大多数治疗方法只能减缓关节炎的进展或治疗其症状,难以实现有效治疗以终止关节炎的退行性进程。当非药物治疗无效时,可使用各种药物疗法来治疗骨关节炎。然而,药物治疗可能会产生重大不良反应且费用高昂。因此,人们对替代疗法进行了研究。草药疗法已被证明有望安全有效地管理骨关节炎。实验研究表明,草药提取物和化合物可以减轻炎症、抑制分解代谢过程,并促进对治疗骨关节炎至关重要的合成代谢过程。由于其治疗作用和固有的药理特性,芳香草药常被用作草药疗法。最近的研究表明,芳香植物有治疗骨关节炎的潜力。此外,从芳香植物中提取的具有抗炎和抗氧化特性的精油及其生物活性成分的复杂混合物,也常被用作骨关节炎的辅助疗法。为了开辟新的研究途径,本文广泛讨论了芳香草药(包括植物、精油及其生物活性成分)的有益抗骨关节炎作用。

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