Imrie C W, Allam B F, Ferguson J C
Curr Med Res Opin. 1976;4(2):101-16. doi: 10.1185/03007997609109289.
Hypoalbuminaemia has been consistently observed in a prospective study of 130 patients with acute pancreatitis. A study was initiated, therefore, to find out if the hypocalcaemia of acute pancreatitis could be explained by the associated hypoalbuminaemia. 64.4% of all serum calcium results were in the apparently hypocalcaemic range. A comparable incidence of hypoalbuminaemia was observed. The 'uncorrected' total serum calcium and serum albumin showed a similar pattern in their daily changes and also a significant correlation overall. When correction of serum calcium was made for albumin levels, only 10.9% of all results represented varying degrees of 'true' hypocalcaemia. Mortality and severity of acute pancreatitis related as closely to hypoalbuminaemia as to uncorrected hypocalcaemia. It is concluded that a low serum albumin should be regarded as the most common cause of a low serum calcium in acute pancreatitis. Routine albumin administration is proposed, a procedure which has been shown to be associated with improved mortality rate and morbidity in this disease.
在一项对130例急性胰腺炎患者的前瞻性研究中，一直观察到低白蛋白血症。因此，开展了一项研究，以确定急性胰腺炎的低钙血症是否可由相关的低白蛋白血症来解释。所有血清钙检测结果中有64.4%处于明显低钙血症范围内。观察到低白蛋白血症的发生率与之相当。“未校正的”总血清钙和血清白蛋白在每日变化中呈现相似模式，总体上也存在显著相关性。当根据白蛋白水平校正血清钙时，所有结果中只有10.9%代表不同程度的“真正”低钙血症。急性胰腺炎的死亡率和严重程度与低白蛋白血症的关系和与未校正的低钙血症的关系一样密切。得出的结论是，血清白蛋白水平低应被视为急性胰腺炎血清钙水平低的最常见原因。建议常规给予白蛋白，这一措施已被证明与改善该疾病的死亡率和发病率相关。
