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本文引用的文献

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Elevated levels of circulating interleukin-18 in human immunodeficiency virus-infected individuals: role of peripheral blood mononuclear cells and implications for AIDS pathogenesis.人类免疫缺陷病毒感染个体中循环白细胞介素-18水平升高：外周血单个核细胞的作用及其对艾滋病发病机制的影响
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Increased gene expression of tumor necrosis factor superfamily ligands in peripheral blood mononuclear cells during chronic heart failure.慢性心力衰竭期间外周血单个核细胞中肿瘤坏死因子超家族配体的基因表达增加。
Cardiovasc Res. 2002 Apr;54(1):175-82. doi: 10.1016/s0008-6363(02)00238-9.
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Development, characterization and use of monoclonal antibodies against sTRAIL: measurement of sTRAIL by ELISA.抗可溶性肿瘤坏死因子相关凋亡诱导配体单克隆抗体的研制、特性鉴定及应用：酶联免疫吸附测定法检测可溶性肿瘤坏死因子相关凋亡诱导配体
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Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity.自主神经系统活动较高的HIV感染者对高效抗逆转录病毒疗法（HAART）反应受损。
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12695-700. doi: 10.1073/pnas.221134198.
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Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells.白细胞介素-18抑制外周血单个核细胞中1型人类免疫缺陷病毒的产生。
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6
Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu.白细胞介素-18是一种独特的细胞因子，根据其细胞因子环境刺激Th1和Th2反应。
Cytokine Growth Factor Rev. 2001 Mar;12(1):53-72. doi: 10.1016/s1359-6101(00)00015-0.
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Interleukin-18 regulates both Th1 and Th2 responses.白细胞介素-18调节Th1和Th2反应。
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8
Enhancement of lymphocyte proliferation induced by interleukin-12 and anti-interleukin-10 in HIV-infected patients during highly active antiretroviral therapy.在高效抗逆转录病毒治疗期间，白细胞介素-12和抗白细胞介素-10对HIV感染患者淋巴细胞增殖的增强作用。
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10
Enhanced expression of the CXCR4 co-receptor in HIV-1-infected individuals correlates with the emergence of syncytia-inducing strains.在HIV-1感染个体中，共受体CXCR4的表达增强与合胞体诱导株的出现相关。
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白细胞介素-18血清水平升高与疾病进展相关，且可能导致HIV-1感染患者的病毒学治疗失败。

Raised serum levels of interleukin-18 is associated with disease progression and may contribute to virological treatment failure in HIV-1-infected patients.

作者信息

Stylianou E, Bjerkeli V, Yndestad A, Heggelund L, Waehre T, Damås J K, Aukrust P, Frøland S S

机构信息

Section of Clinical Immunology and Infectious Diseases, Rikshospitalet University Hospital, Oslo, Norway.

出版信息

Clin Exp Immunol. 2003 Jun;132(3):462-6. doi: 10.1046/j.1365-2249.2003.02179.x.

DOI:10.1046/j.1365-2249.2003.02179.x
PMID:12780693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1808719/
Abstract

To gain further insight into the possible role of interleukin (IL)-18 in HIV-1 infection we examined serum levels of IL-18 in various clinical and immunological stages of HIV-1 infection during cross-sectional (n = 41) and longitudinal testing (n = 20) and during HAART (n = 21, 24 months follow-up). Our main findings were that HIV-1-infected patients had significantly raised IL-18 levels comparing healthy controls, particularly in those with advanced disease, that while HAART induced a marked decline in IL-18, virological treatment failure was associated with persistently raised IL-18 levels during such therapy and that our in vitro experiments showed an IL-18-mediated up-regulation of the HIV-1 coreceptor CXCR4 and the pro-apoptotic mediator TRAIL in PBMC from HIV-1-infected patients receiving HAART. HIV-1 infection appears to be characterized by persistently raised IL-18 levels and during HAART, such a pattern was associated with virological treatment failure, possibly contributing to immunodeficiency and HIV-1 replication in these patients.

摘要

为了进一步深入了解白细胞介素（IL）-18在HIV-1感染中可能发挥的作用，我们在横断面研究（n = 41）、纵向检测（n = 20）以及高效抗逆转录病毒治疗（HAART，n = 21，随访24个月）期间，检测了处于HIV-1感染不同临床和免疫阶段患者的血清IL-18水平。我们的主要发现包括：与健康对照相比，HIV-1感染患者的IL-18水平显著升高，尤其是在疾病晚期患者中；虽然HAART使IL-18水平显著下降，但病毒学治疗失败与治疗期间IL-18水平持续升高有关；我们的体外实验表明，IL-18可介导接受HAART的HIV-1感染患者外周血单核细胞（PBMC）中HIV-1共受体CXCR4和促凋亡介质TRAIL的上调。HIV-1感染似乎以IL-18水平持续升高为特征，在HAART期间，这种模式与病毒学治疗失败有关，可能导致这些患者的免疫缺陷和HIV-1复制。