White J M L, Powell A M, Brady K, Russell-Jones R
Department of Dermatology, Ealing Hospital, London, UK.
Clin Exp Dermatol. 2003 May;28(3):254-6. doi: 10.1046/j.1365-2230.2003.01214.x.
Argyria is a rare cause of cutaneous discolouration caused by silver deposition. We report a case of dramatic and diffuse argyria secondary to ingestion of colloidal silver protein over a 1-year period. Stained electron microscopy with spectral analysis was used to confirm the clinical diagnosis. Silver-protein complexes are deposited in the skin and reduced to inert silver salts by sunlight in a process similar to that harnessed in photography. Our patient had obtained the silver for consumption via mail order. It had been advertised as a cure for a variety of diseases. Colloidal silver protein is commercially available as a 'food supplement', hence circumventing the strict controls placed on medicines.
银质沉着病是一种由银沉积引起的罕见皮肤变色病因。我们报告一例因在1年时间内摄入胶体银蛋白继发的显著且弥漫性银质沉着病病例。采用染色电子显微镜光谱分析来确诊临床诊断。银-蛋白质复合物沉积于皮肤，并通过类似于摄影过程中利用的阳光作用还原为惰性银盐。我们的患者通过邮购获取用于食用的银。它被宣传为可治愈多种疾病。胶体银蛋白作为“食品补充剂”在市场上有售，从而规避了对药品的严格管控。
