1,4 - 二羟基 - 2,3 - 二氧杂三环[8.4.0.0(4,9)]十四烷及其对恶性疟原虫、布氏锥虫、克氏锥虫和婴儿利什曼原虫具有体外活性的衍生物。
1,4-Dihydroxy-2,3-dioxatricyclo[8.4.0.0(4,9)]tetradecane and derivatives with in vitro activity against Plasmodium falciparum, Trypanasoma b brucei, Trypanasoma cruzi, and Leishmaniasis infantum.
作者信息
Howarth Joshua, Wilson Darragh
机构信息
School of Chemical Sciences, Dublin City University, Glasnevin, Dublin, 9, Ireland.
出版信息
Bioorg Med Chem Lett. 2003 Jun 16;13(12):2013-5. doi: 10.1016/s0960-894x(03)00326-3.
Abstract
1,4-Dihydroxy-2,3-dioxatricyclo[8.4.0.0(4,9)]tetradecane and derivatives have been synthesised and their in vitro activity against Plasmodium falciparum (malaria) Ghana, Trypanasoma b brucei (sleeping sickness) TB-1, and Trypanasoma cruzi (Chagas' disease) TC-1, and Leishmaniasis infantum (leishmaniasis) L1 parasite strains has been assessed.
摘要
已合成了1,4 - 二羟基 - 2,3 - 二氧杂三环[8.4.0.0(4,9)]十四烷及其衍生物，并评估了它们对恶性疟原虫（疟疾）加纳株、布氏锥虫（昏睡病）TB - 1株、克氏锥虫（恰加斯病）TC - 1株以及婴儿利什曼原虫（利什曼病）L1寄生虫株的体外活性。
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