豚鼠主动脉条中的钙内流和接头后超敏反应
Calcium influx and postjunctional supersensitivity in guinea pig aortic strips.
作者信息
Kaiman M, Shibata S
出版信息
Eur J Pharmacol. 1976 May;37(1):213-6. doi: 10.1016/0014-2999(76)90026-1.
PMID:1278243
Abstract
Both reserpine and 6-hydroxydopamine (6-OHDA) pretreatment potentiated the sensitivity of guinea pig aortic strips to norepinephrine (NE), barium, methoxamine and potassium indicating postjunctional supersensitivity. However, cocaine treatmetn only potentiated the NE response indicating prejunctional supersensitivity. 6-OHDA and reserpine-induced supersensitivity but not cocaine-induced supersensitivity was accompanied by an increase in 45Ca influx.
摘要
利血平和6-羟基多巴胺（6-OHDA）预处理均增强了豚鼠主动脉条对去甲肾上腺素（NE）、钡、甲氧明和钾的敏感性，表明存在节后超敏反应。然而，可卡因处理仅增强了NE反应，表明存在节前超敏反应。6-OHDA和利血平诱导的超敏反应而非可卡因诱导的超敏反应伴随着45Ca内流增加。
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