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豚鼠主动脉条中的钙内流和接头后超敏反应

Calcium influx and postjunctional supersensitivity in guinea pig aortic strips.

作者信息

Kaiman M, Shibata S

出版信息

Eur J Pharmacol. 1976 May;37(1):213-6. doi: 10.1016/0014-2999(76)90026-1.

DOI:10.1016/0014-2999(76)90026-1
PMID:1278243
Abstract

Both reserpine and 6-hydroxydopamine (6-OHDA) pretreatment potentiated the sensitivity of guinea pig aortic strips to norepinephrine (NE), barium, methoxamine and potassium indicating postjunctional supersensitivity. However, cocaine treatmetn only potentiated the NE response indicating prejunctional supersensitivity. 6-OHDA and reserpine-induced supersensitivity but not cocaine-induced supersensitivity was accompanied by an increase in 45Ca influx.

摘要

利血平和6-羟基多巴胺(6-OHDA)预处理均增强了豚鼠主动脉条对去甲肾上腺素(NE)、钡、甲氧明和钾的敏感性,表明存在节后超敏反应。然而,可卡因处理仅增强了NE反应,表明存在节前超敏反应。6-OHDA和利血平诱导的超敏反应而非可卡因诱导的超敏反应伴随着45Ca内流增加。

相似文献

1
Calcium influx and postjunctional supersensitivity in guinea pig aortic strips.豚鼠主动脉条中的钙内流和接头后超敏反应
Eur J Pharmacol. 1976 May;37(1):213-6. doi: 10.1016/0014-2999(76)90026-1.
2
Mechanisms by which smooth muscle sensitivity may be altered by calcium.钙可能改变平滑肌敏感性的机制。
Blood Vessels. 1978;15(1-3):93-109. doi: 10.1159/000158156.
3
Sensitivity of guinea pig aorta to norepinphrine, phenylephrine, methoxamine and potassium: effect of reserpine, 6-hydroxydopamine and cocaine.豚鼠主动脉对去甲肾上腺素、苯肾上腺素、甲氧明和钾的敏感性:利血平、6-羟基多巴胺和可卡因的作用
Proc West Pharmacol Soc. 1975;18:93-5.
4
The effects of denervation, cocaine, 6-hydroxydopamine and reserpine on the characteristics of drug-induced contractions of the depolarized smooth muscle of the rat and guinea-pig vas deferens.去神经、可卡因、6-羟基多巴胺和利血平对大鼠和豚鼠输精管去极化平滑肌药物诱导收缩特性的影响。
J Pharmacol Exp Ther. 1977 May;201(2):267-75.
5
Effects of potassium and norepinephrine on calcium influx in guinea-pig vas deferens.钾离子和去甲肾上腺素对豚鼠输精管钙内流的影响。
Eur J Pharmacol. 1987 Aug 4;140(1):55-62. doi: 10.1016/0014-2999(87)90633-9.
6
Calcium influx and spontaneous phasic contractions of portal veins after treatment with reserpine, 6-hydroxydopamine, and cocaine.利血平、6-羟基多巴胺和可卡因处理后门静脉的钙内流及自发性节律性收缩
Can J Physiol Pharmacol. 1978 Apr;56(2):199-201. doi: 10.1139/y78-028.
7
Effect of cold storage on the sensitivity of and calcium influx into rat, rabbit and guinea pig portal veins.冷藏对大鼠、兔和豚鼠门静脉敏感性及钙内流的影响。
Blood Vessels. 1978;15(4):217-30. doi: 10.1159/000158168.
8
Role of calcium in postjunctional supersensitivity.钙在接头后超敏反应中的作用。
Fed Proc. 1975 Sep;34(10):1975-80.
9
The relationship between calcium and increased sensitivity of rabbit aortae four hours after reserpine.利血平作用四小时后兔主动脉中钙与敏感性增加之间的关系。
Br J Pharmacol. 1976 Apr;56(4):449-55. doi: 10.1111/j.1476-5381.1976.tb07457.x.
10
Hyperthyroidism induces supersensitivity to biogenic amines in rat vascular tissue via a pre- and a postjunctional mechanism.甲状腺功能亢进通过一种突触前和突触后机制诱导大鼠血管组织对生物胺产生超敏反应。
J Pharmacol Exp Ther. 1988 Mar;244(3):1027-35.

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