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利血平、6-羟基多巴胺和可卡因处理后门静脉的钙内流及自发性节律性收缩

Calcium influx and spontaneous phasic contractions of portal veins after treatment with reserpine, 6-hydroxydopamine, and cocaine.

作者信息

Kaiman M, Shibata S

出版信息

Can J Physiol Pharmacol. 1978 Apr;56(2):199-201. doi: 10.1139/y78-028.

DOI:10.1139/y78-028
PMID:638871
Abstract

Reserpine treatment increased the amplitude of the spontaneous phasic contraction (SPC) of portal veins obtained from rabbit and guinea pig but did not alter that of rat. The amplitude of the SPC of portal veins from these animals was increased after 6-hydroxydopamine (6-OHDA) but was not changed after cocaine treatment. Reserpine- and 6-OHDA-induced changes in portal vein SPC amplitude were accompanied by an increase in 45Ca influx. These results indicate that the elevation in SPC amplitude is accompanied by an increase in calcium influx.

摘要

利血平处理增加了从兔和豚鼠获得的门静脉自发性相性收缩(SPC)的幅度,但对大鼠门静脉的SPC幅度没有影响。这些动物门静脉的SPC幅度在6-羟基多巴胺(6-OHDA)处理后增加,但在可卡因处理后没有变化。利血平和6-OHDA诱导的门静脉SPC幅度变化伴随着45Ca内流的增加。这些结果表明,SPC幅度的升高伴随着钙内流的增加。

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Can J Physiol Pharmacol. 1978 Apr;56(2):199-201. doi: 10.1139/y78-028.
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Br J Pharmacol. 1995 Apr;114(7):1414-8. doi: 10.1111/j.1476-5381.1995.tb13363.x.

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