Kaiman M, Shibata S
Blood Vessels. 1978;15(1-3):93-109. doi: 10.1159/000158156.
6-Hydroxydopamine (6-OHDA) increased the sensitivity of rat, rabbit and guinea pig portal veins to norepinephrine (NE), methoxamine (ME), barium (Ba++) and calcium (Ca++) but not to potassium (K+). Reserpine potentiated the responses of NE, ME and Ca++ but not Ba++ or K+ in rabbit and guinea pig veins and did not alter the sensitivity of rat veins to all agonists tested. Cocaine only potentiated the NE responses of the veins and decreased the sensitivity of rabbit and guinea pig veins to K+. 6-OHDA increased 48Ca-influx in all veins whereas reserpine increased 45Ca-influx only in rabbit and guinea pig veins. Cocaine failed to increase 45Ca-influx in all veins tested. NE, ME and K+ increased 45Ca-influx in the veins from the different animals. The agonist-induced 45Ca-influx was greater in most of the supersensitive veins than in the control veins. In veins that failed to develop supersensitivity, agonist-induced 45Ca-influx did not differ from that of the control veins. It is concluded that the development of super- and subsensitivity exhibits species variation and that the alteration in Ca++ influx would be consistent with the changes in sensitivity of the venous smooth muscle.
6-羟基多巴胺（6-OHDA）增加了大鼠、兔和豚鼠门静脉对去甲肾上腺素（NE）、甲氧明（ME）、钡（Ba++）和钙（Ca++）的敏感性，但对钾（K+）不敏感。利血平增强了兔和豚鼠静脉对NE、ME和Ca++的反应，但对Ba++或K+无增强作用，且不改变大鼠静脉对所有测试激动剂的敏感性。可卡因仅增强了静脉对NE的反应，并降低了兔和豚鼠静脉对K+的敏感性。6-OHDA增加了所有静脉中的48Ca内流，而利血平仅增加了兔和豚鼠静脉中的45Ca内流。可卡因未能增加所有测试静脉中的45Ca内流。NE、ME和K+增加了不同动物静脉中的45Ca内流。在大多数超敏静脉中，激动剂诱导的45Ca内流大于对照静脉。在未产生超敏反应的静脉中，激动剂诱导的45Ca内流与对照静脉无差异。结论是，超敏和低敏的发展表现出种属差异，并且Ca++内流的改变与静脉平滑肌敏感性的变化一致。
