Jonas Jost B, Harazny Joanna, Budde Wido M, Mardin Christian Y, Papastathopoulos Konstantinos I, Michelson Georg
Department of Ophthalmology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
J Glaucoma. 2003 Jun;12(3):260-5. doi: 10.1097/00061198-200306000-00014.
To examine the relationship between morphologic optic disc parameters and hemodynamic parameters as measured by confocal laser scanning Doppler flowmetry in patients with normal-pressure glaucoma.
The study included 91 eyes of 54 patients with normal-pressure glaucoma (mean age: 57.7 +/- 9.8 years), and 136 eyes of 77 age-adjusted normal controls. Color stereo optic disc photographs were morphometrically examined, and confocal laser scanning flowmetry (Heidelberg Retinal Flowmeter) in the neuroretinal rim inside of the optic disc, and in the retina close to the temporal and nasal border of the optic nerve head was performed.
Mean confocal laser scanning flowmetric measurements in the neuroretinal rim, temporal parapapillary retina, and nasal parapapillary retina were significantly (P<0.03) lower in the normal-pressure glaucoma group than in the age-adjusted control group. Correspondingly, mean confocal laser scanning flowmetric measurements within the neuroretinal rim decreased significantly, with relatively low correlation coefficients, decreasing neuroretinal rim area (P = 0.016; correlation coefficient r2 = 0.026), and increasing mean visual field defect (P = 0.011; r2 = 0.029). Measurements were statistically independent of alpha zone (P = 0.38; r2 = 0.004) and beta zone (P = 0.57; r2 = 0.002) of parapapillary atrophy.
Confocal laser scanning flowmetric measurements within the neuroretinal rim were lower in eyes with normal-pressure glaucoma than in age-matched normal eyes. Confocal laser scanning flowmetric measurements decrease with increasing glaucomatous optic nerve damage. There is, however, a marked variability preventing a clear relationship between stage of glaucoma and decrease in confocal laser scanning flowmetric measurements. The correlation between parapapillary atrophy and confocal laser scanning flowmetric measurements is not statistically significant in normal-pressure glaucoma.
研究正常眼压性青光眼患者通过共焦激光扫描多普勒血流仪测量的形态学视盘参数与血流动力学参数之间的关系。
该研究纳入了54例正常眼压性青光眼患者的91只眼（平均年龄：57.7±9.8岁），以及77例年龄匹配的正常对照者的136只眼。对视盘彩色立体照片进行形态测量，并在视盘内的神经视网膜边缘以及靠近视神经乳头颞侧和鼻侧边缘的视网膜处进行共焦激光扫描血流测量（海德堡视网膜血流仪）。
正常眼压性青光眼组神经视网膜边缘、视乳头旁颞侧视网膜和视乳头旁鼻侧视网膜的平均共焦激光扫描血流测量值显著低于年龄匹配的对照组（P<0.03）。相应地，神经视网膜边缘内的平均共焦激光扫描血流测量值显著下降，相关系数相对较低，神经视网膜边缘面积减小（P = 0.016；相关系数r2 = 0.026），平均视野缺损增加（P = 0.011；r2 = 0.029）。测量结果在统计学上与视乳头旁萎缩的α区（P = 0.38；r2 = 0.004）和β区（P = 0.57；r2 = 0.002）无关。
正常眼压性青光眼患者的神经视网膜边缘内共焦激光扫描血流测量值低于年龄匹配的正常眼。共焦激光扫描血流测量值随青光眼性视神经损伤的增加而降低。然而，存在明显的变异性，使得青光眼分期与共焦激光扫描血流测量值降低之间的关系不明确。在正常眼压性青光眼中，视乳头旁萎缩与共焦激光扫描血流测量值之间的相关性无统计学意义。
