Meyer Tanya K, Rhee John S, Smith Michelle M, Cruz Michael J, Osipov Vladamir O, Wackym Phillip A
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, Wisconsin 53226, USA.
Head Neck. 2003 Jun;25(6):505-10. doi: 10.1002/hed.10216.
Eccrine spiradenocarcinoma is a rare dermal appendage carcinoma believed to arise from transformation of a long-standing benign spiradenoma. This tumor demonstrates highly malignant biologic behavior with a high recurrence rate, frequent lymph node metastases, and overall poor survival.
We report the first case of eccrine spiradenocarcinoma arising in the external auditory canal. The management of this tumor, its histopathologic characteristics, and a review of literature are presented.
A literature review identified 17 cases of eccrine spiradenocarcinoma in the head and neck region. Local recurrence occurred in 58.8% of patients, with an average of 23 months from diagnosis. Lymph node metastasis occurred in 35.3%, with an average of 31 months from diagnosis. Other metastatic sites included skin, bone, and lung. Disease-specific mortality was 22.2%.
Eccrine spiradenocarcinoma is an aggressive tumor with a poor prognosis. Primary treatment should include wide local excision with or without regional lymphadenectomy. Isolated successful treatments have been documented with adjuvant hormonal manipulation, chemotherapy, and radiation therapy.
小汗腺螺旋腺癌是一种罕见的皮肤附属器癌，据信由长期存在的良性螺旋腺瘤恶变而来。该肿瘤表现出高度恶性的生物学行为，复发率高，常发生淋巴结转移，总体生存率低。
我们报告了首例发生于外耳道的小汗腺螺旋腺癌病例。介绍了该肿瘤的治疗情况、组织病理学特征并对文献进行了综述。
文献综述确定了17例头颈部小汗腺螺旋腺癌病例。58.8%的患者出现局部复发，从诊断到复发的平均时间为23个月。35.3%的患者发生淋巴结转移，从诊断到转移的平均时间为31个月。其他转移部位包括皮肤、骨骼和肺部。疾病特异性死亡率为22.2%。
小汗腺螺旋腺癌是一种侵袭性肿瘤，预后较差。主要治疗方法应包括广泛局部切除，可联合或不联合区域淋巴结清扫。有文献记载，辅助激素治疗、化疗和放疗单独应用也取得了成功。
