偏头痛中由刺激引发的视觉扭曲与神经元活动亢进有关。
Visual distortion provoked by a stimulus in migraine associated with hyperneuronal activity.
作者信息
Huang Jie, Cooper Thomas G, Satana Banu, Kaufman David I, Cao Yue
机构信息
Department of Radiology, Michigan State University, East Lansing, MI 48824, USA.
出版信息
Headache. 2003 Jun;43(6):664-71. doi: 10.1046/j.1526-4610.2003.03110.x.
BACKGROUND
Migraineurs with visual aura are highly susceptible to illusions and visual distortion and are particularly sensitive to a pattern of regularly spaced parallel lines or stripes.
PURPOSE
To determine whether the high degree of susceptibility to illusions and visual distortion in migraineurs with aura is associated with hyperneurological activity of the occipital cortex.
METHODS
In order to investigate any relationships among neuronal activity, spatial frequency of square-wave gratings, and self-described visual distortion, we investigated the neuronal and psychophysical responses to square-wave gratings in migraineurs with visual aura and in nonheadache controls.
RESULTS
Square-wave gratings provoked various types of visual distortion and illusions and induced a hyperneuronal response in the visual cortex of migraineurs with visual aura, a response that strongly depended upon the stimulus spatial frequency.
CONCLUSION
The hyperneuronal activity of the occipital cortex is consistent with general cortical hyperexcitability in migraine.
背景
有视觉先兆的偏头痛患者极易出现错觉和视觉扭曲，对规则排列的平行线或条纹图案尤为敏感。
目的
确定有先兆的偏头痛患者对错觉和视觉扭曲的高度易感性是否与枕叶皮质的神经活动亢进有关。
方法
为了研究神经元活动、方波光栅的空间频率和自我描述的视觉扭曲之间的关系，我们调查了有视觉先兆的偏头痛患者和非头痛对照者对方波光栅的神经元和心理物理学反应。
结果
方波光栅引发了各种类型的视觉扭曲和错觉，并在有视觉先兆的偏头痛患者的视觉皮层中诱发了神经元反应亢进，这种反应强烈依赖于刺激的空间频率。
结论
枕叶皮质的神经元活动亢进与偏头痛中普遍的皮质兴奋性过高一致。
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