McKendrick Allison M, Badcock David R
School of Psychology, University of Western Australia, Crawley, Western Australia, Australia.
Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1061-70. doi: 10.1167/iovs.03-0936.
To determine whether perimetric performance is worse the day after a migraine than prior interictal measurements, and if so, to determine whether differences have resolved by 1 week after migraine.
Twenty-two nonheadache control subjects (aged 18-45 years) and 22 migraineurs (aged 18-45 years: 10 migraine with visual aura, 12 migraine without aura) participated. Standard automated perimetry (SAP) and temporal modulation perimetry (TMP) were measured by perimeter (model M-700; Medmont, Pty Ltd., Camberwell, Victoria, Australia). Control subjects attended two test visits: baseline and retest. Migraineurs attended three times: baseline (>or=4 days after migraine), the day after the offset of the next migraine, and 7 days later. Groups were compared using the global indices of the perimeter: Average Defect (AD) and Pattern Defect (PD), in addition to point-wise comparisons.
Group migraineur TMP performance was significantly worse the day after a migraine, showing decreased general sensitivity and increased localized loss. Performance measured 7 days later was not significantly different from that measured the day after a migraine. Group migraineur SAP performance was not significantly worse after migraine; however, a subgroup of six eyes from five patients had 10 or more visual field locations with decreases in sensitivity greater than control test-retest 95% confidence limits.
Decreased visual field performance was present after migraine, as well as greater test-retest variability in the migraine group compared with control subjects. As migraineurs constitute 10% to 15% of the general population, the presence of this subgroup of patients with periodic prolonged decreased visual field sensitivity after migraine has implications for differential clinical diagnosis, and for clinical research using perimetry.
确定偏头痛发作后次日的视野检查表现是否比发作间期之前的测量结果更差，若如此，则确定偏头痛发作1周后差异是否已消除。
22名无头痛对照受试者（年龄18 - 45岁）和22名偏头痛患者（年龄18 - 45岁：10名有视觉先兆偏头痛患者，12名无先兆偏头痛患者）参与研究。使用视野计（型号M - 700；Medmont有限公司，坎伯韦尔，维多利亚，澳大利亚）进行标准自动视野检查（SAP）和颞部调制视野检查（TMP）。对照受试者参加两次测试：基线测试和复测。偏头痛患者参加三次测试：基线测试（偏头痛发作后≥4天）、下一次偏头痛发作结束后次日以及7天后。除逐点比较外，还使用视野计的总体指标：平均缺损（AD）和模式缺损（PD）对各组进行比较。
偏头痛患者组的TMP表现在偏头痛发作后次日显著更差，表现为总体敏感度降低和局部性视野缺损增加。7天后测量的表现与偏头痛发作后次日测量的结果无显著差异。偏头痛患者组的SAP表现偏头痛发作后无显著更差；然而，来自5名患者的6只眼亚组有10个或更多视野位置的敏感度下降幅度大于对照测试 - 复测95%置信区间。
偏头痛发作后存在视野表现下降，且与对照受试者相比，偏头痛组的测试 - 复测变异性更大。由于偏头痛患者占普通人群的10%至15%，偏头痛发作后出现这一周期性长期视野敏感度降低的患者亚组对鉴别临床诊断以及使用视野检查的临床研究具有影响。
