评估自闭症和精神分裂症听觉事件相关电位的试验间变异性。
Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia.
机构信息
Department of Psychology and Center for Integrative Neuroscience, University of Nevada, Reno, Reno, NV, USA.
Department of Psychology and the Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
出版信息
J Autism Dev Disord. 2023 Dec;53(12):4856-4871. doi: 10.1007/s10803-022-05771-0. Epub 2022 Oct 7.
Abstract
Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability.
摘要
感觉异常是自闭症和精神分裂症的特征。在自闭症中，感觉神经反应的trial-to-trial 可变性（TTV）更大，表明该系统更不稳定。然而，这些发现仅在神经反应的幅度而不是时间上得到了确认，并且在精神分裂症中尚未得到充分探索。在自闭症、精神分裂症和对照组中，评估了听觉失匹配负波（MMN）中事件相关电位幅度和trial-to-trial 相干性（ITC）的 TTV。自闭症中的 MMN 最大，精神分裂症中最小，与对照组相比，自闭症和精神分裂症中的 TTV 更大。ITC 没有差异。更大的 TTV 似乎是自闭症和精神分裂症的共同特征，暗示了几种可能导致感觉不稳定的神经机制。
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