Abidia A, Laden G, Kuhan G, Johnson B F, Wilkinson A R, Renwick P M, Masson E A, McCollum P T
Academic Surgical Unit, University of Hull and Hull Royal Infirmary, Hull, U.K.
Eur J Vasc Endovasc Surg. 2003 Jun;25(6):513-8. doi: 10.1053/ejvs.2002.1911.
ischaemic lower-extremity ulcers in the diabetic population are a source of major concern because of the associated high risk of limb-threatening complications. The aim of this study was to evaluate the role of hyperbaric oxygen in the management of these ulcers.
eighteen diabetic patients with ischaemic, non-healing lower-extremity ulcers were recruited in a double-blind study. Patients were randomly assigned either to receive 100% oxygen (treatment group) or air (control group), at 2.4 atmospheres of absolute pressure for 90 min daily (total of 30 treatments).
healing with complete epithelialisation was achieved in five out of eight ulcers in the treatment group compared to one out of eight ulcers in the control group. The median decrease of the wound areas in the treatment group was 100% and in the control group was 52% (p=0.027). Cost-effectiveness analysis has shown that despite the extra cost involved in using hyperbaric oxygen, there was a potential saving in the total cost of treatment for each patient during the study.
hyperbaric oxygen enhanced the healing of ischaemic, non-healing diabetic leg ulcers and may be used as a valuable adjunct to conventional therapy when reconstructive surgery is not possible.
糖尿病患者的下肢缺血性溃疡因伴有肢体威胁性并发症的高风险而成为主要关注来源。本研究的目的是评估高压氧在这些溃疡治疗中的作用。
在一项双盲研究中招募了18名患有缺血性、不愈合下肢溃疡的糖尿病患者。患者被随机分配接受100%氧气（治疗组）或空气（对照组），在绝对压力2.4个大气压下每天治疗90分钟（共30次治疗）。
治疗组8个溃疡中有5个实现了完全上皮化愈合，而对照组8个溃疡中只有1个。治疗组伤口面积的中位数减少了100%，对照组为52%（p = 0.027）。成本效益分析表明，尽管使用高压氧涉及额外成本，但在研究期间每位患者的治疗总成本仍有潜在节省。
高压氧可促进缺血性、不愈合糖尿病腿部溃疡的愈合，在无法进行重建手术时，可作为传统治疗的有价值辅助手段。
