兰尼碱对抗IgE诱导的大鼠腹膜肥大细胞组胺释放的影响。
Effect of ryanodine on histamine release from rat peritoneal mast cells induced by anti-IgE.
作者信息
Takei M, Ueno M, Endo K
机构信息
Department of Pharmacology, Tokushima Bunri University, Japan.
出版信息
J Pharm Pharmacol. 1992 Jun;44(6):523-5. doi: 10.1111/j.2042-7158.1992.tb03660.x.
Abstract
Ryanodine strongly inhibited histamine release from rat peritoneal mast cells induced by anti-IgE. Ryanodine also inhibited Ca(2+)-mobilization from the intracellular Ca(2+)-store as well as histamine release in mast cells activated by anti-IgE. These results suggest that the effect of ryanodine on histamine release from rat mast cells might be due to the inhibition of Ca2+ release from the intracellular Ca2+ store.
摘要
Ryanodine强烈抑制抗IgE诱导的大鼠腹膜肥大细胞组胺释放。Ryanodine还抑制抗IgE激活的肥大细胞中细胞内钙库的钙动员以及组胺释放。这些结果表明，Ryanodine对大鼠肥大细胞组胺释放的作用可能是由于抑制了细胞内钙库的钙释放。
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