Takei M, Urashima H, Endo K
Department of Pharmacology, Tokushima Bunri University, Japan.
Agents Actions. 1991 Mar;32(3-4):213-6. doi: 10.1007/BF01980876.
Dantrolene strongly and dose-dependently inhibited histamine release from rat peritoneal mast cells induced by anti-IgE. Dantrolene inhibited Ca(2+)-mobilization from intracellular Ca(2+)-store as well as histamine release in mast cells activated by anti-IgE, the effect on both these phenomena being closely correlated. These results suggested that the effect of dantrolene on histamine release from rat mast cell might be due to the inhibition of Ca(2+)-release from intracellular Ca(2+)-store.
丹曲林能强烈且剂量依赖性地抑制抗IgE诱导的大鼠腹膜肥大细胞组胺释放。丹曲林抑制抗IgE激活的肥大细胞内钙库的Ca(2+)动员以及组胺释放，对这两种现象的作用密切相关。这些结果提示，丹曲林对大鼠肥大细胞组胺释放的作用可能是由于抑制了细胞内钙库的Ca(2+)释放。
