Wirth Sylvia, Yanike Marianna, Frank Loren M, Smith Anne C, Brown Emery N, Suzuki Wendy A
Center for Neural Science, New York University, New York, NY 10003, USA.
Science. 2003 Jun 6;300(5625):1578-81. doi: 10.1126/science.1084324.
The medial temporal lobe is crucial for the ability to learn and retain new declarative memories. This form of memory includes the ability to quickly establish novel associations between unrelated items. To better understand the patterns of neural activity during associative memory formation, we recorded the activity of hippocampal neurons of macaque monkeys as they learned new associations. Hippocampal neurons signaled learning by changing their stimulus-selective response properties. This change in the pattern of selective neural activity occurred before, at the same time as, or after learning, which suggests that these neurons are involved in the initial formation of new associative memories.
内侧颞叶对于学习和保留新的陈述性记忆的能力至关重要。这种记忆形式包括在不相关项目之间快速建立新关联的能力。为了更好地理解联想记忆形成过程中的神经活动模式，我们记录了猕猴海马神经元在学习新关联时的活动。海马神经元通过改变其刺激选择性反应特性来表明学习情况。选择性神经活动模式的这种变化发生在学习之前、学习期间或学习之后，这表明这些神经元参与了新联想记忆的初始形成。
