Muramatsu T, Miyauchi T
Department of Biochemistry, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan.
Histol Histopathol. 2003 Jul;18(3):981-7. doi: 10.14670/HH-18.981.
Basigin (Bsg) is a transmembrane glycoprotein with two immunoglobulin-like domains, and forms a family with embigin and neuroplastin. In these proteins a conserved glutamic acid is present in the middle for the transmembrane domain. Bsg is also called CD147 and EMMPRIN, and the symbol for the human basigin gene is BSG. BSG is located in chromosome 19 band p13. 3. Knockout mice deficient in the Bsg gene are sterile and show various neurological abnormalities. Bsg-deficient embryos are also difficult to implant. Bsg has been found to participate in the cell-surface orientation of monocarboxylic acid transporters (MCTs) to the plasma membrane. Dysfunction of the retina in Bsg-deficient mice is ascribed to the failure of plasma membrane integration of MCTs in the tissue. Bsg is also involved in inflammatory processes and is proposed to be a receptor of cyclophilin A; it is also likely to participate in HIV infection. Bsg in tumor cells triggers the production or release of matrix metalloproteinases in the surrounding mesenchymal cells and tumor cells, thereby contributing to tumor invasion. Furthermore, the association of Bsg with integrins might be important in signaling through Bsg.
基底结合素（Bsg）是一种具有两个免疫球蛋白样结构域的跨膜糖蛋白，与embigin和神经塑膜蛋白构成一个家族。在这些蛋白质中，跨膜结构域中间存在一个保守的谷氨酸。Bsg也被称为CD147和细胞外基质金属蛋白酶诱导因子（EMMPRIN），人类基底结合素基因的符号是BSG。BSG位于19号染色体p13.3带。缺乏Bsg基因的基因敲除小鼠不育，并表现出各种神经异常。缺乏Bsg的胚胎也难以着床。已发现Bsg参与单羧酸转运蛋白（MCTs）在细胞膜上的定位。缺乏Bsg的小鼠视网膜功能障碍归因于该组织中MCTs未能整合到质膜中。Bsg也参与炎症过程，有人提出它是亲环素A的受体；它也可能参与HIV感染。肿瘤细胞中的Bsg触发周围间充质细胞和肿瘤细胞中基质金属蛋白酶的产生或释放，从而促进肿瘤侵袭。此外，Bsg与整合素的关联在通过Bsg进行信号传导中可能很重要。
