Ghanayem N S, Yee L, Nelson T, Wong S, Gordon J B, Marcdante K, Rice T B
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, USA.
Pediatr Crit Care Med. 2001 Oct;2(4):315-7. doi: 10.1097/00130478-200110000-00005.
The current practice of preparing fresh dopamine and epinephrine solutions every 24 hrs may lead to hemodynamic instability caused by the interruption of infusions with each change. We determined the stability of these catecholamines over an 84-hr period and whether stability was enhanced by dextrose-containing solutions.
Tertiary care teaching hospital.
The stability of dopamine and epinephrine, each at three commonly used concentrations, was studied in three vehicles (10 gm/dl dextrose in water [D10W], 5 gm/dl dextrose in water [D5W], and 0.9% NaCl in water [NS]). To mimic clinical conditions, solutions were placed on syringe pumps infusing continuously into a closed system at ambient temperature for 84 hrs.
Concentrations of dopamine in mg/ml and epinephrine in microg/ml were measured by high-performance liquid chromatography at 0, 24, 36, 48, 72, and 84 hrs.
Dopamine and epinephrine concentrations did not change over the 84-hr period regardless of the vehicles in which the drugs were prepared.
Clinically relevant concentrations of dopamine and epinephrine remain stable in dextrose- and saline-containing solutions for >or=84 hrs. These data suggest that solutions of these catecholamines may safely be used in clinical practice beyond the currently recommended 24 hrs.
目前每24小时配制新鲜多巴胺和肾上腺素溶液的做法，可能会因每次更换输液而导致输液中断，进而引起血流动力学不稳定。我们测定了这些儿茶酚胺在84小时内的稳定性，以及含葡萄糖溶液是否能增强其稳定性。
三级护理教学医院。
在三种溶媒（10%葡萄糖注射液[D10W]、5%葡萄糖注射液[D5W]和0.9%氯化钠注射液[NS]）中，研究了三种常用浓度的多巴胺和肾上腺素的稳定性。为模拟临床情况，将溶液置于注射泵上，在环境温度下连续输注到一个封闭系统中84小时。
在0、24、36、48、72和84小时，通过高效液相色谱法测量多巴胺的浓度（mg/ml）和肾上腺素的浓度（μg/ml）。
无论药物是在何种溶媒中配制，多巴胺和肾上腺素的浓度在84小时内均未发生变化。
临床相关浓度的多巴胺和肾上腺素在含葡萄糖和盐水的溶液中可保持稳定≥84小时。这些数据表明，这些儿茶酚胺溶液在临床实践中使用的时间可以超过目前推荐的24小时。
