Sanoski Cynthia A
Department of Pharmacy Practice and Pharmacy Administration, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA.
Curr Atheroscler Rep. 2003 Jul;5(4):284-90. doi: 10.1007/s11883-003-0051-9.
Despite the wealth of clinical evidence that demonstrates a reduction in the risk of coronary heart disease with the use of various lipid-lowering therapies, many patients in the United States are untreated or inadequately treated with these agents. Although the most recent treatment guidelines developed by the National Cholesterol Education Program provide detailed information regarding risk assessment of patients and desired lipid and lipoprotein goals, practitioners need to stay current on any emerging data that may have a significant impact on the management of patients with dyslipidemia. Over the past 2 years, the results of several clinical trials that may prompt the initiation of lipid-lowering therapy in a broader range of patients have been published. This article reviews the findings of these important clinical trials and provides some insight as to how these findings can be incorporated into clinical practice.
尽管大量临床证据表明,使用各种降脂疗法可降低冠心病风险,但美国仍有许多患者未接受这些药物治疗或治疗不充分。虽然国家胆固醇教育计划制定的最新治疗指南提供了有关患者风险评估以及理想血脂和脂蛋白目标的详细信息,但从业者需要及时了解任何可能对血脂异常患者管理产生重大影响的新数据。在过去两年中,多项临床试验结果已发表,这些结果可能促使在更广泛的患者中启动降脂治疗。本文回顾了这些重要临床试验的结果,并就如何将这些结果纳入临床实践提供了一些见解。