Kobayashi Y, Gotoh M, Mandel W J, Karagueuzian H S
Cedars-Sinai Medical Center, Department of Medicine, UCLA School of Medicine 90048.
Pacing Clin Electrophysiol. 1992 Nov;15(11 Pt 2):2194-9. doi: 10.1111/j.1540-8159.1992.tb03046.x.
The degree of temporo-spatial variation of repolarization during single (S2) and double (S3) premature stimulation was evaluated in five closed-chest anesthetized dogs. Monophasic action potentials (MAP) were simultaneously recorded with contact electrode and MAP duration (MAPD) restitution curves constructed from right ventricular (RV) and left ventricular (LV) endocardial sites. At a given coupling interval, S3 was associated with significantly greater dispersion of MAPD then S2 (spatial dispersion, i.e., between RV and LV). Similarly, at a given diastolic interval, S3 at RV and LV sites, was associated with significantly greater dispersion of MAPD then S2 (temporal dispersion). It is concluded that S3 is associated with greater temporo-spatial dispersion of repolarization then S2.
在五只开胸麻醉犬中评估了单次（S2）和双次（S3）早搏刺激期间复极化的时空变化程度。使用接触电极同时记录单相动作电位（MAP），并构建右心室（RV）和左心室（LV）心内膜部位的MAP持续时间（MAPD）恢复曲线。在给定的耦合间期，S3与MAPD的离散度显著大于S2（空间离散度，即RV和LV之间）。同样，在给定的舒张间期，RV和LV部位的S3与MAPD的离散度显著大于S2（时间离散度）。得出的结论是，S3与比S2更大的复极化时空离散度相关。
