Fiori Alessandro, Mason Thomas L, Fox Thomas D
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.
Eukaryot Cell. 2003 Jun;2(3):651-3. doi: 10.1128/EC.2.3.651-653.2003.
The 5'-untranslated leaders of mitochondrial mRNAs appear to localize translation within the organelle. VAR1 is the only yeast mitochondrial gene encoding a major soluble protein. A chimeric mRNA bearing the VAR1 untranslated regions and the coding sequence for pre-Cox2p appears to be translated at the inner membrane surface. We propose that translation of the ribosomal protein Var1p is also likely to occur in close proximity to the inner membrane.
线粒体mRNA的5'非翻译前导序列似乎将翻译定位在细胞器内。VAR1是酵母中唯一编码一种主要可溶性蛋白的线粒体基因。带有VAR1非翻译区和前Cox2p编码序列的嵌合mRNA似乎在内膜表面进行翻译。我们推测核糖体蛋白Var1p的翻译也可能在内膜附近发生。
