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从大鼠肝微粒体孵育介质中分离并通过质谱鉴定FK 506的两种代谢产物。

Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media.

作者信息

Lhoëst G, Maton N, Verbeeck R

机构信息

Department of Pharm. Sc.-UCL, Brussels, Belgium.

出版信息

Pharm Acta Helv. 1992;67(9-10):270-4.

PMID:1279730
Abstract

A transient epoxide in equilibrium with its possible isomeric forms, most probably induced easily by neighboring-group assistance of a hydroxy group, and a dihydrodiol formed under the influence of the hydrase enzymic activity and/or by simple hydrolysis were isolated by HPLC and identified by FAB/MS from rat liver microsomal incubation media.

摘要

通过高效液相色谱（HPLC）从大鼠肝微粒体孵育介质中分离出一种与可能的异构形式处于平衡状态的瞬态环氧化物，其很可能由羟基的邻基协助作用轻易诱导产生，以及一种在水合酶活性影响下和/或通过简单水解形成的二氢二醇，并通过快原子轰击质谱（FAB/MS）进行鉴定。

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引用本文的文献

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