Isolation and identification by FAB mass spectrometry and NMR spectroscopy of a demethylated metabolite of FK506 from erythromycin-induced rabbit liver microsomes.
作者信息
Lhoëst G, Maton N, Verbeeck R
机构信息
Department of Pharm. Sciences--UCL, Laboratory of Mass Spectrometry, Brussels, Belgium.
出版信息
Pharm Acta Helv. 1993;68(1):35-41. doi: 10.1016/0031-6865(93)90006-r.
PMID:7692454
Abstract
A new demethylated metabolite, extracted from erythromycin-induced rabbit liver microsomes incubation media, isolated by HPLC and identified by FAB/MS and NMR, is described. Moreover, NMR spectra suggest the existence of tautomeric forms of this O-demethylated metabolite of FK506.
摘要
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