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Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes.

作者信息

Lhoëst G, Maton N, Verbeeck R K

机构信息

Department of Pharmaceutical Sciences-UCL, Laboratory of Mass Spectrometry (FATC), Brussels, Belgium.

出版信息

Drug Metab Dispos. 1993 Sep-Oct;21(5):850-4.

PMID:7694828
Abstract

A novel metabolite of FK-506-a C13, C15, C31 O-demethyl C19 hydroxymethyl C36 isomerized epoxide of FK-506 obtained from erythromycin-induced rabbit liver microsomes--was isolated by HPLC and identified by FAB/MS and NMR. The existence of ring-chain tautomers for this metabolite is demonstrated by NMR spectroscopy. FAB/MS, and HPLC.

摘要

相似文献

1
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引用本文的文献

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Clin Pharmacokinet. 2002;41(11):813-51. doi: 10.2165/00003088-200241110-00003.
2
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