Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes.
作者信息
Lhoëst G, Maton N, Verbeeck R K
机构信息
Department of Pharmaceutical Sciences-UCL, Laboratory of Mass Spectrometry (FATC), Brussels, Belgium.
出版信息
Drug Metab Dispos. 1993 Sep-Oct;21(5):850-4.
PMID:7694828
Abstract
A novel metabolite of FK-506-a C13, C15, C31 O-demethyl C19 hydroxymethyl C36 isomerized epoxide of FK-506 obtained from erythromycin-induced rabbit liver microsomes--was isolated by HPLC and identified by FAB/MS and NMR. The existence of ring-chain tautomers for this metabolite is demonstrated by NMR spectroscopy. FAB/MS, and HPLC.
摘要
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