Vargas-Serrato Esmeralda, Corredor Vladimir, Galinski Mary R
Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, N.E., Atlanta, GA 30329, USA.
Infect Genet Evol. 2003 May;3(1):67-73. doi: 10.1016/s1567-1348(03)00007-8.
Plasmodium coatneyi is a simian malaria parasite with various biological features similar to the human malaria P. falciparum and potential as a model for severe cases of malaria. We have characterized two single-copy genes from P. coatneyi, the circumsporozoite protein and merozoite surface protein-9 genes, and determined its phylogenetic relationship among Plasmodium species. This study demonstrates that while it has similarities to P. falciparum, P. coatneyi belongs to a distant clade including several simian malaria parasites and the human malaria P. vivax. P. coatneyi forms a monophyletic group with P. knowlesi, demonstrating their close relationship despite some very distinctive biological characteristics.
科氏疟原虫是一种猿类疟原虫，具有多种与人类疟原虫恶性疟原虫相似的生物学特征，有潜力作为重症疟疾病例的模型。我们已对科氏疟原虫的两个单拷贝基因，即环子孢子蛋白基因和裂殖子表面蛋白9基因进行了特征分析，并确定了它在疟原虫物种中的系统发育关系。这项研究表明，虽然科氏疟原虫与恶性疟原虫有相似之处，但它属于一个较远的进化枝，包括几种猿类疟原虫和人类疟原虫间日疟原虫。科氏疟原虫与诺氏疟原虫形成一个单系群，表明它们尽管有一些非常独特的生物学特征，但关系密切。
