Davis Sabrina, Bozon Bruno, Laroche Serge
Laboratoire de Neurobiologie de l'Apprentissage, de la Mémoire et de la, Communications, UMR CNRS 8620, Université Paris Sud, 91405 Orsay Cedex, France.
Behav Brain Res. 2003 Jun 16;142(1-2):17-30. doi: 10.1016/s0166-4328(02)00421-7.
The immediate early genes (IEGs) are activated rapidly and transiently in response to a multitude of stimuli. The zif268 belongs to a category of regulatory IEGs that activate downstream target genes and is considered to be a triggering mechanism to activate the genomic response in neurons. Several studies have shown that zif268 mRNA is upregulated during different forms of associative learning, and following tetanic stimulation that induces long-lasting LTP. To date, there is a general consensus that zif268 activation may constitute a critical mechanism for the encoding of long-lasting memories, however this is based on relatively few studies. Given the fact that zif268 can be activated by a number of different types of stimuli, it becomes important to determine exactly how it may be implicated in memory. Examination of the current literature suggests that zif268 is necessary in the processing of several types of memory, however, it is not entirely clear what aspects of memory zif268 may be implicated in. Here, we review the existing literature and emphasise that understanding the signalling pathways that lead to activation of the IEGs and the downstream targets of these genes will advance our understanding of how functional activation of zif268 may be implicated in processing long-term memories.
即刻早期基因（IEGs）在受到多种刺激后会迅速且短暂地被激活。zif268属于一类调节性即刻早期基因，可激活下游靶基因，被认为是激活神经元基因组反应的触发机制。多项研究表明，在不同形式的联想学习过程中以及在诱导长时程增强（LTP）的强直刺激后，zif268 mRNA会上调。迄今为止，人们普遍认为zif268的激活可能是长期记忆编码的关键机制，然而这是基于相对较少的研究得出的结论。鉴于zif268可被多种不同类型的刺激激活，确定其在记忆中的确切作用方式变得尤为重要。对现有文献的研究表明，zif268在多种记忆处理过程中是必需的，然而，目前尚不完全清楚zif268可能涉及记忆的哪些方面。在此，我们回顾现有文献，并强调了解导致即刻早期基因激活的信号通路以及这些基因的下游靶点，将有助于我们深入理解zif268的功能性激活在长期记忆处理中的作用机制。
