Bozon Bruno, Davis Sabrina, Laroche Serge
Laboratoire de Neurobiologie de l'Apprentissage de la Mémoire et de la Communication, CNRS UMR 8620, Université Paris-Sud, 91405 Orsay, France.
Neuron. 2003 Nov 13;40(4):695-701. doi: 10.1016/s0896-6273(03)00674-3.
Recent research has revived interest in the possibility that previously consolidated memories need to reconsolidate when recalled to return to accessible long-term memory. Evidence suggests that both consolidation and reconsolidation of certain types of memory require protein synthesis, but whether similar molecular mechanisms are involved remains unclear. Here, we explore whether zif268, an activity-dependent inducible immediate early gene (IEG) required for consolidation of new memories, is also recruited for reconsolidation of recognition memory following reactivation. We show that when a consolidated memory for objects is recalled, zif268 mutant mice are impaired in further long-term but not short-term recognition memory. The impairment is specific to reactivation with the previously memorized objects in the relevant context, occurs in delayed recall, and does not recover over several days. These findings indicate that IEG-mediated transcriptional regulation in neurons is one common molecular mechanism for the storage of newly formed and reactivated recognition memories.
先前巩固的记忆在被回忆时需要重新巩固，以便回到可提取的长期记忆状态。有证据表明，某些类型记忆的巩固和重新巩固都需要蛋白质合成，但其中是否涉及相似的分子机制仍不清楚。在此，我们探究zif268（一种新记忆巩固所需的活性依赖型诱导即时早期基因（IEG））在重新激活后是否也会被募集用于识别记忆的重新巩固。我们发现，当对物体的巩固记忆被回忆时，zif268突变小鼠在进一步的长期识别记忆方面受损，但短期识别记忆未受影响。这种损伤特定于在相关情境中用先前记忆的物体进行重新激活时出现，在延迟回忆中出现，并且在数天内不会恢复。这些发现表明，神经元中IEG介导的转录调控是新形成和重新激活的识别记忆存储的一种常见分子机制。
