Yu Kuo Long, Zhang Yi, Civiello Rita L, Kadow Kathleen F, Cianci Christopher, Krystal Mark, Meanwell Nicholas A
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5, Research Parkway, 06492, Wallingford, CT, USA.
Bioorg Med Chem Lett. 2003 Jul 7;13(13):2141-4. doi: 10.1016/s0960-894x(03)00383-4.
Structure-activity relationships surrounding the dialkylamino side chain of a series of benzotriazole-derived inhibitors of respiratory syncytial virus fusion based on the screening lead 1a were examined. The results indicate that the topology of the side chain is important but the terminus element offers considerable latitude to modulate physical properties.
基于筛选先导化合物1a，研究了一系列呼吸道合胞病毒融合抑制剂的苯并三唑衍生物的二烷基氨基侧链周围的构效关系。结果表明，侧链的拓扑结构很重要，但末端基团在调节物理性质方面有相当大的自由度。
