Fei Xiangshu, Zheng Qi Huang, Liu Xuan, Wang Ji Quan, Sun Hui Bin, Mock Bruce H, Stone K Lee, Miller Kathy D, Sledge George W, Hutchins Gary D
Department of Radiology, Indiana University School of Medicine, IN 46202, Indianapolis, USA.
Bioorg Med Chem Lett. 2003 Jul 7;13(13):2217-22. doi: 10.1016/s0960-894x(03)00382-2.
Novel matrix metalloproteinase (MMP) inhibitor radiotracers, (S)-3-methyl-2-(2',3',4'-methoxybiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1a-c), (S)-3-methyl-2-(2',3',4'-fluorobiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1d-f), and (S)-3-methyl-2-(4'-nitrobiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents.
新型基质金属蛋白酶（MMP）抑制剂放射性示踪剂，（S）-3-甲基-2-（2'，3'，4'-甲氧基联苯-4-磺酰氨基）-丁酸[（11）C]甲酯（1a-c）、（S）-3-甲基-2-（2'，3'，4'-氟联苯-4-磺酰氨基）-丁酸[（11）C]甲酯（1d-f）以及（S）-3-甲基-2-（4'-硝基联苯-4-磺酰氨基）-丁酸[（11）C]甲酯（1g），一系列取代联苯磺酰胺衍生物，已被合成用于评估作为新型潜在的正电子发射断层扫描（PET）癌症成像剂。
