Reichart P A, Dietrich T, Khongkhunthian P, Srisuwan S
Medical Faculty of Humboldt University, Charité, Department of Oral Surgery and Dental Radiology, Berlin, Germany.
Oral Oncol. 2003 Sep;39(6):569-73. doi: 10.1016/s1368-8375(03)00039-3.
A decline of oropharyngeal cancer has already been predicted for Thailand since the early 1960s. To substantiate these predictions it was the purpose of this study to examine trends in the incidence of oropharyngeal cancer in the province of Chiangmai, (1988-1999). Data on cancer incidence were extracted from the annual reports of the Cancer Registry, Cancer Unit, Faculty of Medicine, Chiangmai University, Thailand (1992-1999) and an IARC report on cancer in Thailand (1988-1991). The age-standardized annual incidence per 100000 of oral cancer in males dropped from 3.6 (1988-1991) to 1.2 in 1999 (P for trend 0.0002) and in females from 2.6 (1988-1991) to 1.1 in 1999 (P for trend 0.007). Similar trends in males and females for cancer of the tongue, oropharynx and hypopharynx were seen. The age-standardized annual incidence for cancer of the lip, salivary gland and nasopharyngeal carcinoma remained unchanged. Changes of traditional oral habits such as betel quid chewing and smoking of traditional cigars seem to have resulted in a marked decrease of oral cancer in both men and women in the recent past.
自20世纪60年代初以来，泰国就已预测口咽癌发病率会下降。为证实这些预测，本研究旨在调查清迈府（1988 - 1999年）口咽癌发病率的趋势。癌症发病率数据取自泰国清迈大学医学院癌症登记处癌症科的年度报告（1992 - 1999年）以及一份关于泰国癌症的国际癌症研究机构报告（1988 - 1991年）。男性每10万人口中口腔癌的年龄标准化年发病率从1988 - 1991年的3.6降至1999年的1.2（趋势P值为0.0002），女性从1988 - 1991年的2.6降至1999年的1.1（趋势P值为0.007）。舌癌、口咽癌和下咽癌在男性和女性中也呈现类似趋势。唇癌、唾液腺癌和鼻咽癌的年龄标准化年发病率保持不变。近期，诸如嚼槟榔和吸传统雪茄等传统口腔习惯的改变似乎导致了男性和女性口腔癌发病率显著下降。
