Tarvainen L, Suuronen R, Lindqvist C, Malila N
Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Helsinki, Helsinki, Finland.
Oral Dis. 2004 May;10(3):167-72. doi: 10.1046/j.1601-0825.2003.00999.x.
The aim of this study was to describe the occurrence of oral and pharyngeal cancer in Finland over the last half century.
The study included all lip, oral and pharyngeal cancer cases diagnosed in Finland and reported to the nation-wide Finnish Cancer Registry between 1953 and 1999.
The study comprised 17,383 new cancer cases: 11,666 in males and 5717 in females. Of these, 83% were squamous cell carcinomas. By the end of the study, 1999, the mean age at diagnosis had increased to 63 years for males and 67 for females. The age-adjusted incidence of oral and pharyngeal cancer decreased in males from 12.5 per 10(5) to 8.4 per 10(5) while it increased in females from 3.0 per 10(5) to 3.9 per 10(5). This was because of a decrease in lip cancer incidence in males, while the incidence of tongue, mouth and salivary gland cancers increased in both genders. The annual number of new oral cancer cases increased, however, in both genders.
The incidence of lip cancer decreased in males, probably because of a decrease in smoking and in outdoor work. The incidence of intra-oral cancers increased in both genders, possibly because of increased alcohol consumption.
本研究旨在描述芬兰过去半个世纪口腔和咽癌的发病情况。
该研究纳入了1953年至1999年间在芬兰诊断出并报告给全国性芬兰癌症登记处的所有唇、口腔和咽癌病例。
该研究包含17383例新发癌症病例，其中男性11666例，女性5717例。这些病例中，83%为鳞状细胞癌。到研究结束的1999年，男性诊断时的平均年龄增至63岁，女性为67岁。口腔和咽癌的年龄调整发病率在男性中从每10万12.5例降至每10万8.4例，而在女性中从每10万3.0例增至每10万3.9例。这是因为男性唇癌发病率下降，而舌、口腔和唾液腺癌的发病率在两性中均有所上升。然而，两性中新发口腔癌病例的年度数量均有所增加。
男性唇癌发病率下降，可能是由于吸烟减少和户外工作减少。两性中口腔内癌症的发病率均有所上升，可能是由于酒精消费增加。
