DeSimone Christopher P, Lele Subodh M, Modesitt Susan C
Division of Gynecologic Oncology, Department of OB/GYN, University of Kentucky Markey Cancer Center, 800 Rose Street, Lexington, KY 40536-0298, USA.
Gynecol Oncol. 2003 Jun;89(3):543-8. doi: 10.1016/s0090-8258(03)00141-0.
Malignant struma ovarii is a rare type of germ cell tumor that is most often diagnosed postoperatively. The natural history and optimal treatment regimen for the disease are essentially unknown due to the small numbers of published cases.
A 32-year-old woman presented with pelvic pain and an ovarian mass that was ultimately treated by total abdominal hysterectomy/bilateral salpingo-oophorectomy. Postoperatively, she was diagnosed with a malignant struma ovarii. The patient was subsequently treated with thyroidectomy and I(131) ablation and is currently disease free. A Medline literature search was performed and clinical data from 23 additional cases were compiled.
In this review of 24 cases, 16 patients were followed conservatively postoperatively while 8 received varied additional therapy (4 with I(131)). There were 8 recurrences and all occurred in the conservatively managed patients. I(131) for recurrent disease provided an initial complete response in 7 women. Treatment with thyroidectomy and I(131) should be considered in the first line of management for malignant struma ovarii.
恶性卵巢甲状腺肿是一种罕见的生殖细胞肿瘤，最常在术后确诊。由于已发表的病例数量较少，该疾病的自然史和最佳治疗方案基本未知。
一名32岁女性因盆腔疼痛和卵巢肿块就诊，最终接受了全腹子宫切除术/双侧输卵管卵巢切除术。术后，她被诊断为恶性卵巢甲状腺肿。该患者随后接受了甲状腺切除术和碘（131）消融治疗，目前无疾病。进行了Medline文献检索，并汇编了另外23例病例的临床数据。
在对这24例病例的回顾中，16例患者术后接受保守治疗，8例接受了不同的额外治疗（4例接受碘（131）治疗）。有8例复发，均发生在接受保守治疗的患者中。碘（131）治疗复发性疾病使7名女性获得了初始完全缓解。对于恶性卵巢甲状腺肿，应考虑将甲状腺切除术和碘（131）治疗作为一线治疗方法。
