University Digestive Health Care Center Basel - Clarunis, Department of Visceral Surgery, St. Claraspital and University Hospital Basel, Basel, 4002, Switzerland.
St. Clara Research Ltd, Basel, 4058, Switzerland.
BMC Endocr Disord. 2024 Jun 10;24(1):85. doi: 10.1186/s12902-024-01606-4.
Teratomas are germ cell tumors composed of somatic tissues from up to three germ layers. Primary retroperitoneal teratomas usually develop during childhood and are uncommon in adults and in the retroperitoneal space. While there are only a few cases of retroperitoneal thyroid tissue, we report a unique case of a retroperitoneal papillary thyroid carcinoma.
A 41-year-old woman presented in our institution due to intermitted unspecific abdominal pain. Magnetic resonance imaging detected a multi-cystic solid retroperitoneal mass ventral to the psoas muscle and the left iliac artery. After surgical removal of the retroperitoneal mass, histology sections of the specimen indicated evidence of papillary thyroid carcinoma cells. A staging computed tomography scan of the body showed no further manifestations. To reduce the risk of recurrence, total thyroidectomy was performed followed by radioiodine therapy with lifelong hormone substitution.
Primary retroperitoneal teratoma with evidence of papillary thyroid carcinoma is a rare condition. Preoperative diagnosis is difficult due to its non-specific clinical manifestation and lack of specific radiologic findings. Histopathology analysis is necessary for diagnosis. Although surgery is considered the first line treatment, there is still discussion about the extent of resection and the need for total thyroidectomy with adjuvant radioiodine therapy.
畸胎瘤是由来自三个胚层的体组织组成的生殖细胞肿瘤。原发性腹膜后畸胎瘤通常在儿童期发展,在成人和腹膜后空间中并不常见。虽然腹膜后甲状腺组织的病例很少,但我们报告了一例独特的腹膜后甲状腺乳头状癌病例。
一名 41 岁女性因间歇性非特异性腹痛到我院就诊。磁共振成像检测到腰大肌和左髂动脉腹侧的多房性囊性腹膜后肿块。腹膜后肿块切除后,标本的组织学切片显示有甲状腺乳头状癌细胞的证据。全身分期 CT 扫描未显示进一步表现。为降低复发风险,进行了全甲状腺切除术,随后进行了放射性碘治疗和终身激素替代治疗。
原发性腹膜后畸胎瘤伴甲状腺乳头状癌是一种罕见的情况。由于其非特异性临床表现和缺乏特定的影像学发现,术前诊断困难。组织病理学分析是必要的诊断方法。尽管手术被认为是一线治疗方法,但对于切除范围和是否需要全甲状腺切除术联合辅助放射性碘治疗仍存在争议。