Duesberg Peter, Koehnlein Claus, Rasnick David
Donner Laboratory, University of California Berkeley, Berkeley, CA 94720, USA.
J Biosci. 2003 Jun;28(4):383-412. doi: 10.1007/BF02705115.
In 1981 a new epidemic of about two-dozen heterogeneous diseases began to strike non-randomly growing numbers of male homosexuals and mostly male intravenous drug users in the US and Europe. Assuming immunodeficiency as the common denominator the US Centers for Disease Control (CDC) termed the epidemic, AIDS, for acquired immunodeficiency syndrome. From 1981-1984 leading researchers including those from the CDC proposed that recreational drug use was the cause of AIDS, because of exact correlations and of drug-specific diseases. However, in 1984 US government researchers proposed that a virus, now termed human immunodeficiency virus (HIV), is the cause of the non-random epidemics of the US and Europe but also of a new, sexually random epidemic in Africa. The virus-AIDS hypothesis was instantly accepted, but it is burdened with numerous paradoxes, none of which could be resolved by 2003: Why is there no HIV in most AIDS patients, only antibodies against it? Why would HIV take 10 years from infection to AIDS? Why is AIDS not self-limiting via antiviral immunity? Why is there no vaccine against AIDS? Why is AIDS in the US and Europe not random like other viral epidemics? Why did AIDS not rise and then decline exponentially owing to antiviral immunity like all other viral epidemics? Why is AIDS not contagious? Why would only HIV carriers get AIDS who use either recreational or anti-HIV drugs or are subject to malnutrition? Why is the mortality of HIV-antibody-positives treated with anti-HIV drugs 7-9%, but that of all (mostly untreated) HIV-positives globally is only 1.4%? Here we propose that AIDS is a collection of chemical epidemics, caused by recreational drugs, anti-HIV drugs, and malnutrition. According to this hypothesis AIDS is not contagious, not immunogenic, not treatable by vaccines or antiviral drugs, and HIV is just a passenger virus. The hypothesis explains why AIDS epidemics strike non-randomly if caused by drugs and randomly if caused by malnutrition, why they manifest in drug- and malnutrition-specific diseases, and why they are not self-limiting via anti-viral immunity. The hypothesis predicts AIDS prevention by adequate nutrition and abstaining from drugs, and even cures by treating AIDS diseases with proven medications.
1981年，一场由大约二十多种不同疾病构成的新疫情开始非随机地侵袭美国和欧洲越来越多的男同性恋者以及主要为男性的静脉注射吸毒者。美国疾病控制中心（CDC）假定免疫缺陷是这些疾病的共同特征，将这场疫情命名为艾滋病，即获得性免疫缺陷综合征。1981年至1984年期间，包括疾病控制中心的研究人员在内的顶尖研究人员提出，使用消遣性药物是艾滋病的病因，因为存在确切的相关性以及特定药物引发的疾病。然而，1984年美国政府研究人员提出，一种病毒，即现在所说的人类免疫缺陷病毒（HIV），是美国和欧洲非随机疫情的病因，也是非洲一种新的、性传播随机发生的疫情的病因。病毒 - 艾滋病假说立即被接受，但它存在众多自相矛盾之处，到2003年这些矛盾都未能得到解决：为什么大多数艾滋病患者体内没有HIV，只有针对它的抗体？为什么HIV从感染到引发艾滋病需要10年时间？为什么艾滋病不会通过抗病毒免疫自我限制？为什么没有艾滋病疫苗？为什么美国和欧洲的艾滋病不像其他病毒疫情那样随机传播？为什么艾滋病没有像所有其他病毒疫情那样，因抗病毒免疫而先上升然后呈指数下降？为什么艾滋病没有传染性？为什么只有使用消遣性药物、抗HIV药物或营养不良的HIV携带者会得艾滋病？为什么接受抗HIV药物治疗的HIV抗体阳性者的死亡率为7 - 9%，而全球所有（大多数未接受治疗）HIV阳性者的死亡率仅为1.4%？在此我们提出，艾滋病是由消遣性药物、抗HIV药物和营养不良引发的一系列化学性疫情。根据这一假说，艾滋病没有传染性，不具有免疫原性，不能通过疫苗或抗病毒药物治疗，而HIV只是一种过客病毒。该假说解释了如果艾滋病由药物引起为何疫情非随机发生，如果由营养不良引起为何随机发生，为何它们表现为特定药物和营养不良引发的疾病，以及为何它们不会通过抗病毒免疫自我限制。该假说预测可通过充足营养和戒除药物来预防艾滋病，甚至可用经证实有效的药物治疗艾滋病疾病来治愈。
