Bentwich Z, Kalinkovich A, Weisman Z
R. Ben-Ari Institute of Clinical Immunology, Kaplan Hospital, Hebrew University Hadassah Medical School, Rehovot, Israel.
Immunol Today. 1995 Apr;16(4):187-91. doi: 10.1016/0167-5699(95)80119-7.
The AIDS epidemic in Africa is very different from the epidemic in the West. As suggested here by Zvi Bentwich, Alexander Kalinkovich and Ziva Weisman, this appears to be primarily a consequence of the over-activation of the immune system in the African population, owing to the extremely high prevalence of infections, particularly helminthic, in Africa. Such activation shifts the cytokine balance towards a T helper 0/2 (Th0/2)-type response, which makes the host more susceptible to infection with human immunodeficiency virus (HIV) and less able to cope with it.
非洲的艾滋病疫情与西方的疫情大不相同。正如兹维·本特维奇、亚历山大·卡林科维奇和齐瓦·魏斯曼在此所指出的，这似乎主要是由于非洲人群免疫系统过度激活所致，原因是非洲感染率极高，尤其是蠕虫感染。这种激活使细胞因子平衡转向辅助性T细胞0/2（Th0/2）型反应，这使得宿主更容易感染人类免疫缺陷病毒（HIV），且应对能力更弱。
