Li Qing-lang, Zhang Yue-fei
Department of Cardiology, Affiliated Tongren Hospital, Capital Medical University, Beijing 100730.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 May;23(5):335-7.
To grasp the therapeutic effect of Taizhi'an (TZA) in lowering blood lipid level.
Three hundred patients with hyperlipidemia were randomly divided adopting numerical table method into 7 groups, the Taizhi'an group (A, n = 90), the half-dose Fenofibrate plus Taizhi'an group (B, n = 30), the full-dose Fenofibrate group (C, n = 30), the half-dose Simvastatin plus Taizhi'an group (D, n = 30), the full-dose Simvastatin group (E, n = 30), the Zhibituo group (F, n = 60) and the Xuezhikang group (G, n = 30). The effect in different groups were compared after 8 weeks treatment.
In group A, the total cholesterol (TC) lowered by 12.7%, triglyceride (TG) lowered by 22.1% and the high density lipoprotein cholesterol (HDL-C) increased by 13.1%, the total effective rate being 82%. The therapeutic effect in group B was similar to that in group C, and that in group D was similar to that in group E (P > 0.05). The therapeutic effect of Taizhi'an was similar to that of Xuezhikang and Zhibituo, but was better than Zhibituo in lowering TG, LDL-C and increasing HDL-C, and better than Xuezhikang in lowering TG and increasing HDL-C (P < 0.05).
When Taizhi'an used in combination with half-dose Simvastatin, it could not only enhance the blood lipid regulatory effect of Simvastatin but also reduce the dosage used and alleviate its adverse reaction. Compared with Xuezhikang and Zhibituo, Taizhi'an got the similar therapeutic effect, but was superior in regulating blood lipids.
掌握泰脂安（TZA）降低血脂水平的治疗效果。
采用随机数字表法将300例高脂血症患者分为7组，即泰脂安组（A组，n = 90）、半量非诺贝特加泰脂安组（B组，n = 30）、全量非诺贝特组（C组，n = 30）、半量辛伐他汀加泰脂安组（D组，n = 30）、全量辛伐他汀组（E组，n = 30）、脂必妥组（F组，n = 60）和血脂康组（G组，n = 30）。治疗8周后比较各组疗效。
A组总胆固醇（TC）降低12.7%，甘油三酯（TG）降低22.1%，高密度脂蛋白胆固醇（HDL-C）升高13.1%，总有效率为82%。B组与C组疗效相似，D组与E组疗效相似（P > 0.05）。泰脂安的疗效与血脂康和脂必妥相似，但在降低TG、低密度脂蛋白胆固醇（LDL-C）及升高HDL-C方面优于脂必妥，在降低TG及升高HDL-C方面优于血脂康（P < 0.05）。
泰脂安与半量辛伐他汀联合应用时，不仅可增强辛伐他汀的调脂作用，还可减少用药剂量并减轻其不良反应。与血脂康和脂必妥相比，泰脂安疗效相似，但在调节血脂方面更具优势。
