消脂胶囊治疗高脂血症的临床疗效研究

[Treatment of hyperlipoidemia by xiaozhi capsule: a clinical efficacy research].

作者信息

Wang Jian-Ping, Fan Rui-Hong, Wang Yan, Mei Yan

机构信息

Institute of Sores Ulceration, Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Jun;33(6):736-40.

PMID:23980349

Abstract

OBJECTIVE

To observe the clinical effect and efficacy of Xiaozhi Capsule (XZC), a Chinese medicine preparation for tonifying Gan-Shen, invigorating Pi to dissipate dampness (TGSIPDD) on total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and endothelin (ET) in treating patients with hyperlipidemia.

METHODS

Totally 120 primary hyperlipidemia patients were randomly assigned to the treatment group (80 cases) and the control group (40 cases). Those in the treatment group took XZC, while those in the control group took Xuezhikang Capsule (XZKC). The serum TC, TG, HDL-C, LDL-C, and ET were detected and evaluated after 8 weeks of treatment.

RESULTS

In the treatment group TC was reduced by 25.60%, TG by 33.70%, LDL-C by 32.90%, and ET by 11.02%, while HDL-C was elevated by 24.20%. In the control group, TC was reduced by 24.80%, TG by 33.50%, LDL-C by 31.30%, and ET by 12.05%, while HDL-C was elevated by 20.90%. There was statistical difference in the two groups when compared with before treatment (P < 0.01). But there was no statistical difference in the aforesaid indices between the two groups after treatment (P > 0.05). The integrals for main symptoms after treatment obviously decreased in the two groups, showing statistical difference when compared with before treatment in the same group (P < 0.01). But there was no statistical difference in the aforesaid indices between the two groups (P > 0.05). After 8 weeks of treatment, symptoms such as vertigo, heavy sensation of head, palpitation, chest distress, dry mouth and thirsty were obviously improved after treatment. There was statistical difference in the improvement of tinnitus after treatment in the treatment group (P < 0.01). The total effective rate was 86.25% in the treatment group and 82.50% in the control group, showing no statistical difference (P > 0.05).

CONCLUSIONS

XZC showed certain effects on each blood lipid index and ET of hyperlipidemia patients. It had better improvement of clinical symptoms with reliable efficacy.

摘要

目的

观察中药制剂消脂胶囊（XZC），一种滋补肝肾、健脾祛湿（TGSIPDD）的药物，对高脂血症患者总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和内皮素（ET）的临床疗效。

方法

将120例原发性高脂血症患者随机分为治疗组（80例）和对照组（40例）。治疗组服用消脂胶囊，对照组服用血脂康胶囊（XZKC）。治疗8周后检测并评估血清TC、TG、HDL-C、LDL-C和ET。

结果

治疗组TC降低25.60%，TG降低33.70%，LDL-C降低32.90%，ET降低11.02%，而HDL-C升高24.20%。对照组TC降低24.80%，TG降低33.50%，LDL-C降低31.3%，ET降低%，而HDL-C升高20.90%。与治疗前相比，两组差异有统计学意义（P<0.01）。但治疗后两组上述指标差异无统计学意义（P>0.05）。两组治疗后主要症状积分明显下降，与同组治疗前相比差异有统计学意义（P<0.01）。但两组上述指标差异无统计学意义（P>0.05）。治疗8周后，眩晕、头重感、心悸、胸闷、口干口渴等症状治疗后明显改善。治疗组治疗后耳鸣改善差异有统计学意义（P<0.01）。治疗组总有效率为86.25%，对照组为82.50%，差异无统计学意义（P>0.05）。