Jautová J, Dorko E, Pilipcinec E, Tkáciková L
Department of Dermatology, Faculty of Medicine, Safárik University, 040 66 Kosice, Slovakia.
Folia Microbiol (Praha). 2003;48(2):249-52. doi: 10.1007/BF02930964.
A group of 46 patients with acne vulgaris were prescribed clindamycin in combination with a vaccination therapy using a staphylococci antigenic complex (Polystafana; Sevapharma, Czechia). Acne papulopustulosa was diagnosed in 36 patients and acne indurata in 10 patients. The clinical effect of clindamycin and Polystafana was determined on the basis of the regression of the inflammatory manifestation of acne: regression by 0-30% was considered unsuccessful, by 30-80% satisfactory, and above 80% excellent; the immunomodulation effect of the treatment was evaluated in parallel. The clinical effect was excellent in 21 patients with acne papulopustulosa and in 6 with acne indurata; it was accompanied by pronounced immunomodulation effect as both cellular and humoral immunity was also tended to return to normal values. A satisfactory clinical effect was observed in 15 patients with acne papulopustulosa, whose cellular immunity component was also stimulated. Only 4 patients with acne indurata failed to respond successfully. These were the patients who showed a pronounced deficit of the cellular immunity component persisting even after the treatment. The administration of clindamycin in combination with Polystafana vaccination can be recommended as an effective means for the treatment of acne vulgaris.
一组46例寻常痤疮患者接受了克林霉素联合使用葡萄球菌抗原复合物（Polystafana；Sevapharma，捷克）的疫苗疗法。其中36例诊断为丘疹脓疱性痤疮，10例为硬结性痤疮。根据痤疮炎症表现的消退情况确定克林霉素和Polystafana的临床疗效：消退0 - 30%为治疗失败，30 - 80%为满意，超过80%为优秀；同时并行评估治疗的免疫调节效果。21例丘疹脓疱性痤疮患者和6例硬结性痤疮患者临床疗效优秀，同时伴有明显的免疫调节效果，细胞免疫和体液免疫均趋于恢复正常水平。15例丘疹脓疱性痤疮患者临床疗效满意，其细胞免疫成分也受到刺激。只有4例硬结性痤疮患者治疗未成功，这些患者即使在治疗后仍表现出明显的细胞免疫成分缺陷。克林霉素联合Polystafana疫苗接种可作为治疗寻常痤疮的有效方法推荐使用。
