Greenwood R, Burke B, Cunliffe W J
Br J Dermatol. 1986 Mar;114(3):353-8. doi: 10.1111/j.1365-2133.1986.tb02827.x.
Four hundred and twenty patients with moderate to severe acne vulgaris were treated with oral erythromycin and topical benzoyl peroxide to determine the optimum dose regimes. Our results show that the response was significantly less in patients with a greater severity of acne, with truncal acne and in those with a higher sebum excretion rate. There was a significantly better clinical result in patients given Ig erythromycin daily than in those given 0.5 g daily (plus topical therapy in both groups). The relapse rate on stopping antibiotics is also significantly less in patients given I g daily and this dosage did not produce any increase in side effects. We suggest that any patient requiring oral antibiotics should initially be given I g daily of erythromycin (or tetracycline) for up to six months, plus topical therapy.
420例中度至重度寻常痤疮患者接受口服红霉素和外用过氧化苯甲酰治疗，以确定最佳剂量方案。我们的结果表明，痤疮严重程度较高、患有躯干痤疮以及皮脂排泄率较高的患者反应明显较差。每天给予1g红霉素的患者临床效果明显优于每天给予0.5g红霉素的患者（两组均加用局部治疗）。每天给予1g红霉素的患者停用抗生素后的复发率也明显较低，且该剂量未导致副作用增加。我们建议，任何需要口服抗生素的患者最初应每天给予1g红霉素（或四环素），持续长达6个月，并加用局部治疗。
